The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats.

Hearing Research
Yiwen ZhengCynthia L Darlington

Abstract

Previous studies in animals and humans have shown that, in some cases at least, anti-epileptic drugs can reduce the severity of tinnitus. Given that cannabinoid receptor agonists have been shown to exert anti-epileptic effects in some circumstances, we investigated whether two synthetic CB(1)/CB(2) receptor agonists, WIN55,212-2, and CP55,940, could inhibit the behavioural manifestations of salicylate-induced tinnitus in rats in a conditioned suppression task. We found that neither WIN55,212-2 (3.0 mg/kg s.c) nor CP55,940 (0.1 or 0.3 mg/kg s.c), significantly reduced conditioned behaviour associated with tinnitus. However, both 3 mg/kg WIN55,212-2 and 0.3 mg/kg CP55,940 did significantly increase tinnitus-related behaviour compared to the vehicle control groups. These results suggest that cannabinoid receptor agonists may not be useful in the treatment of salicylate-induced tinnitus and that at certain doses, they could actually exacerbate the condition.

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Citations

May 16, 2014·Neural Plasticity·Wolfger von der Behrens
Dec 14, 2011·Expert Opinion on Emerging Drugs·Berthold Langguth, Ana Belén Elgoyhen
Feb 9, 2010·Journal of Ethnopharmacology·Yiwen ZhengCynthia L Darlington
Dec 7, 2018·Current Opinion in Neurology·Yiwen Zheng, Paul F Smith
Dec 5, 2019·The Journal of the Acoustical Society of America·Avril Genene HoltRichard Altschuler
Dec 18, 2020·Frontiers in Neurology·Paola PerinCinzia Boselli
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Jun 4, 2021·Frontiers in Molecular Neuroscience·Sumana GhoshBradley J Walters

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