PMID: 6103938Mar 1, 1980Paper

The effects of theophylline and caffeine on thermoregulatory functions of rats at different ambient temperatures

The Journal of Pharmacy and Pharmacology
M T LinG G Liu

Abstract

Both systemic and central administration of theophylline and caffeine produced a dose-dependent rise in rectal temperature at ambient temperatures of 8, 22 and 30 degrees C. The hyperthermia in response to either xanthine was brought about by an increase in metabolic heat production. In addition, their administration produced behavioral excitation, cutaneous vasodilation (as estimated by an increase in the foot and tail skin temperatures) and diuresis. There was no change in respiratory evaporative heat loss. Probably, the hyperthermia induced by the two drugs was due to behavioral excitation leading to an increased metabolism at the ambient temperatures studied. Furthermore, either destruction of central catecholaminergic nerve fibres (with 6-hydroxydopamine) or blockade of alpha-adrenergic and dopaminergic (with phentolamine and haloperidol) receptors antagonized the xanthine-induced hyperthermia. The data suggest that these xanthines elicit a central activation of both adrenergic and dopaminergic receptors via release of endogenous catecholamines that leads to behavioral excitation and hyperthermia in rats.

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Citations

Dec 1, 1995·Psychopharmacology·M R ZarrindastM Mohagheghi-Badi
Dec 1, 1995·Psychopharmacology·M R ZarrindastB Shafaghi
May 2, 1994·European Journal of Pharmacology·M R Zarrindast, B Shafaghi
May 12, 1994·European Journal of Pharmacology·M R Zarrindast, M R Heidari
Jun 13, 1996·European Journal of Pharmacology·M R ZarrindastA I Sadeghi
Dec 12, 1983·Life Sciences·S A Wager-SrdarA S Levine
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·S R Ticho, M Radulovacki
Jan 1, 1984·Pharmacology & Therapeutics·W G Clark, J M Lipton
Sep 12, 2002·European Journal of Pharmacology·Mohammad-Reza ZarrindastTaraneh Bahreini
Dec 11, 1999·European Journal of Pharmacology·H SahraeiM R Zarrindast
Sep 28, 1998·Respiration Physiology·H Gautier, C Murariu
Feb 5, 2002·Annual Review of Physiology·Alexandre A Steiner, Luiz G S Branco
Jan 27, 1999·Japanese Journal of Pharmacology·M T HsiehM T Lin
Aug 19, 2006·The Journal of Comparative Neurology·Samüel DeurveilherKazue Semba
Feb 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Céline ChevrierFrédéric Canini
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L G BrancoS C Wood
Sep 14, 1999·The American Journal of Physiology·K C Crisanti, J E Fewell
Dec 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J KoosFanor Bohorquez
May 27, 1985·Life Sciences·T F Lee, L C Wang

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