The effects of thimerosal, a sulfhydryl reagent, on phasic myometrial contractions

Biochemical and Biophysical Research Communications
M Phillippe

Abstract

Thimerosal inhibits calcium uptake and IP3-induced calcium release from IP3-sensitive endoplasmic reticulum; this study sought to evaluate the effects of thimerosal on agonist-stimulated phasic myometrial contractions. Thimerosal was found to significantly inhibit phasic contractions stimulated by oxytocin, aluminum fluoride, potassium chloride, ionomycin, and Bay K 8644. These observations provide support for the hypothesis that calcium uptake and IP3-induced calcium release are important events during agonist-stimulated phasic myometrial contractions.

Citations

Mar 11, 2004·International Journal of Pharmaceutics·Jocimara A M NamurM H Bueno Da Costa
Feb 24, 1997·Biochemical and Biophysical Research Communications·M Phillippe, A Basa
Nov 2, 1999·Biochemical and Biophysical Research Communications·J Ascher-LandsbergM Phillippe

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