The effects of thromboxane A2 inhibitors (OKY-046 and ONO-3708) and leukotriene inhibitors (AA-861 and LY-171883) on CCl4-induced chronic liver injury in mice

Prostaglandins, Leukotrienes, and Essential Fatty Acids
T ShimazawaM Kasahara

Abstract

The effects of OKY-046, a selective thromboxane A2 (TxA2) synthetase inhibitor, ONO-3708, a novel TxA2 receptor antagonist, AA-861, a selective 5-lipoxygenase inhibitor and LY-171883, a peptide leukotrienes (p-LTs) receptor antagonist on the chronic liver injury were investigated in mice. The chronic liver injury was induced by the injection of carbon tetrachloride (CCl4) two times a week for twelve weeks in mice. In chronic liver injury models, significant histopathological changes in the liver and extensive elevation of glutamate transaminase (GOT and GPT) activity were observed. Administration of OKY-046, ONO-3708, AA-861 and LY-171883 for 12 weeks suppressed the elevation of serum GOT and GPT levels and histopathological changes in CCl4-induced chronic liver injury. These results suggest that TxA2 and LTs inhibitors are effective for the onset and development of chronic liver injury in mice.

References

Oct 1, 1989·Japanese Journal of Pharmacology·H NagaiM Kasahara
Dec 1, 1989·Inflammation·H NagaiM Kasahara
Oct 1, 1989·Prostaglandins·H NagaiM Kasahara
Feb 29, 1988·Biochemical and Biophysical Research Communications·M Iwai, K Jungermann
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F GuarnerS Moncada
Jul 1, 1985·Prostaglandins, Leukotrienes, and Medicine·G DavìA Strano
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D KepplerH K Koch
May 1, 1985·Seminars in Liver Disease·K Decker

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Citations

Jan 1, 1994·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·X J Meng, J L Wang
Dec 2, 2008·Prostaglandins & Other Lipid Mediators·Magdalena CuciureanuMihai Nechifor
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KawadaS Yamamoto

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