The effects of TMB-8 on the shape changes of vascular endothelial cells resulting from exposure to various inflammatory agents

Agents and Actions
A M Northover

Abstract

Pre-treatment of the endothelial cells lining the guinea pig inferior vena cava with 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB-8) (10 microM) in vitro significantly reduced the shape changes resulting from subsequent exposure to platelet activating factor (PAF) (0.1 microM), calcium ionophore A23187 (10 microM), histamine (300 microM), bradykinin (2 microM), prostaglandin E2 (PGE2) (30 microM), or leukotrienes (LT) C4, D4 or E4 (1 microM). Since TMB-8 is an intracellular calcium antagonist, this provides evidence to support the suggestion that these inflammatory agents increase the concentration of intracellular calcium which brings about a contraction of the actin-myosin complex resulting in endothelial cell shape changes, and the formation of interendothelial cell gaps.

References

Sep 1, 1987·Circulation Research·G Y Grigorian, U S Ryan
Jul 1, 1987·Journal of Cellular Physiology·A Siflinger-BirnboimA B Malik
Oct 1, 1987·The American Journal of Physiology·R Morgan-BoydA Hassid
Aug 1, 1969·The Journal of Pathology·A M Northover, B J Northover
Sep 1, 1969·The Journal of Cell Biology·G MajnoM Leventhal

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Citations

Jan 1, 1992·Agents and Actions·A M Northover
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W G Mayhan
Jan 1, 1995·Mediators of Inflammation·A M Northover, B J Northover
Dec 24, 1998·Journal of Neurophysiology·P G GreenJ D Levine

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