PMID: 9418759Jan 7, 1998Paper

The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis

Journal of the American Academy of Dermatology
J F BourkeP E Hutchinson

Abstract

Calcipotriol is an effective treatment of chronic plaque psoriasis. We have previously demonstrated that it has a small effect on systemic calcium homeostasis even at recommended doses. We attempted to determine the mechanism of the effect of calcipotriol on systemic calcium homeostasis so we could assess the possible consequences of long-term use. Sixteen patients with extensive chronic plaque psoriasis were hospitalized and treated with high-dose topical calcipotriol. Up to 360 gm of calcipotriol (50 micrograms/gm) ointment was applied per week for 2 weeks under controlled conditions. There was a dose-dependent rise in intestinal absorption of calcium. No effect on bone turnover was demonstrated over this short period. Five patients became hypercalcemic, and there was a dose-dependent rise in serum total adjusted calcium, serum ionized calcium, serum phosphate, urine calcium, and urine phosphate. There was a dose-dependent fall in serum parathyroid hormone and serum 1,25 dihydroxyvitamin D3. Calcipotriol exerts its effects on systemic calcium homeostasis by increasing intestinal absorption of calcium and probably phosphate. This results in suppression of parathyroid hormone and 1,25 dihydroxyvitamin D3.

References

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Citations

Oct 9, 2013·European Journal of Medicinal Chemistry·Wei ShenCan Zhang
Jan 1, 2009·Clinical, Cosmetic and Investigational Dermatology·Lutz Kowalzick
Apr 16, 2008·Journal of the American Academy of Dermatology·Joseph LamMagdalene A Dohil
Oct 21, 2006·Journal of the American Academy of Dermatology·Pearon G Lang, Anne H LeClercq
Aug 7, 2013·Dermatologic Therapy·Olubukola Babalola, Bruce E Strober
Jun 22, 2005·Journal of the American Academy of Dermatology·Alice B Gottlieb
Oct 3, 2003·International Journal of Dermatology·Vikas SharmaBhushan Kumar
Jul 8, 2015·American Journal of Clinical Dermatology·Nannie BangsgaardLone Skov
Jan 13, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·M W F M van DuijnhovenP C M Van de Kerkhof
Jan 5, 2008·International Journal of Dermatology·Gerald S BraunHolger Schmid
Apr 16, 2002·The British Journal of Dermatology·P C M van de KerkhofC Trompke
Oct 10, 1998·The British Journal of Dermatology·T O BleikerP E Hutchinson
Apr 16, 2015·Expert Review of Clinical Immunology·Melissa B HoffmanSteven R Feldman
Aug 15, 2001·The British Journal of Dermatology·L Kowalzick
Mar 24, 2000·The British Journal of Dermatology·R Marks

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