PMID: 7541190Jan 1, 1995Paper

The effects of topical corticosteroids on delayed pressure urticaria

Archives of Dermatological Research
R J BarlowM W Greaves

Abstract

Six patients with delayed pressure urticaria (DPU) applied clobetasol propionate (0.05%) ointment or its base to predetermined test sites on the right and left thigh as part of a randomized, double-blind study. A pressure challenge was administered to each test site at the initial visit and repeated after 3 days and 6 weeks of treatment and at between 4 and 8 weeks after treatment. The areas of pressure-induced weals were measured 6 h after each challenge. At the 6-week visit, a 4-mm punch biopsy was taken from pressure-challenged skin on each test site. Sections were stained for mast cells and immunohistochemical labelling was used to demonstrate neutrophils (neutrophil elastase), eosinophils (eosinophil cationic protein), monocytes/macrophages (EBM 11), cells expressing the beta-2 integrins (CD11/18) and the vascular adhesion molecules, E selectin and intercellular adhesion molecule-1 (ICAM-1). In the steroid-treated sites, there was a significant decrease (P < 0.05, Wilcoxon's matched-pairs test) in the size of the pressure weals compared with baseline at 3 days, 6 weeks and at follow-up. Demonstrable mast cells were significantly decreased (P = 0.059) in the pressure-challenged areas in the steroid-treated sites compared wi...Continue Reading

References

Feb 1, 1988·Archives of Dermatology·Y A MekoriR A Clark
Jun 1, 1988·Journal of the American Academy of Dermatology·J S DoverM W Greaves
Mar 1, 1986·Clinical and Experimental Dermatology·R K WinkelmannM W Greaves
Apr 1, 1986·The Journal of Allergy and Clinical Immunology·K C DavisA L Schocket
Dec 1, 1985·Archives of Dermatology·J BartonG S Lazarus
Jul 1, 1973·The British Journal of Dermatology·R Woodford, B W Barry
Nov 1, 1967·The Journal of Physiology·M Greaves, S Shuster
Nov 1, 1982·The Journal of Allergy and Clinical Immunology·G L SussmanA L Schocket

❮ Previous
Next ❯

Citations

Sep 24, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David M LangJonathan A Bernstein
Aug 10, 2005·The British Journal of Dermatology·A KerstanM Leverkus
Nov 26, 2009·Dermatologic Therapy·Nicoletta CassanoGino Antonio Vena
Sep 24, 2009·Allergy·T ZuberbierUNKNOWN World Allergy Organization
Jan 27, 2006·Allergy·T ZuberbierB Wedi
Jun 30, 2015·Indian Journal of Dermatology·Aayushi MehtaManjyot Gautam
Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Jonathan A BernsteinDana Wallace
Nov 18, 2003·The British Journal of Dermatology·G DawnW S Douglas
Mar 2, 2010·Anais Brasileiros De Dermatologia·Sérgio Duarte DortasAdriana Smith Jorge
Mar 18, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Kanokvalai KulthananMarcus Maurer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.