The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment

Frontiers in Human Neuroscience
Eliana BerraCristina Tassorelli

Abstract

Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This study is a pilot randomized double-blind sham-controlled trial to evaluate the efficacy of ts-DCS on central neuropathic pain in MS patients. Methods: Thirty-three MS patients with central neuropathic pain were enrolled and randomly assigned to two groups in a double-blind sham-controlled design: anodal ts-DCS group (n = 19, 10 daily 20-min sessions, 2 mA) or sham ts-DCS group (n = 14, 10 daily 20-min sessions, 0 mA). The following clinical outcomes were evaluated before ts-DCS treatment (T0), after 10 days of treatment (T1) and 1 month afte...Continue Reading

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Citations

Aug 31, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Letizia LeocaniDiego Centonze
Apr 29, 2020·Expert Opinion on Pharmacotherapy·Clara G ChisariFrancesco Patti
Apr 19, 2020·Current Opinion in Neurology·Diego CentonzePeter Feys
Aug 28, 2020·Expert Review of Medical Devices·Kevin Pacheco-BarriosFelipe Fregni

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Clinical Trials Mentioned

NCT02331654

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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