PMID: 2116745Aug 1, 1990Paper

The effects of transient hyperglycemia on brain glucose in rats anesthetized with halothane

Anesthesiology
M R Weglinski, W L Lanier

Abstract

The effects of transient hyperglycemia on brain glucose and the relationship between blood and brain glucose were studied in 76 Sprague-Dawley rats anesthetized with halothane 1% inspired. In a common control group, blood and brain glucose were determined prior to any intervention (n = 10). A second group of 30 rats was given an iv infusion of 3.9 ml of saline over a 30-min period, and blood and brain glucose were subsequently determined at several time points: 30 min (immediately after the saline infusion), 45, 60, 90, or 120 min (n = 6 for each time point). A third group of 36 rats was administered 3 g/kg of glucose in 3.9 ml of iv saline over a similar 30-min period, and blood and brain glucose were measured at the same time periods as in saline-treated rats and also when half of the glucose infusion was given (time = 15 min; n = 6 for each time point). In the common control group, blood glucose was 114 +/- 14 mg/dl (6.4 +/- 0.8 mumol/ml; mean +/- SD) and brain glucose was 2.41 +/- 0.59 mumol/g. Saline infusion had no effect on brain or blood glucose. In contrast, glucose infusion in the study group produced significant increases in both blood and brain glucose, achieving maximal values of 488 +/- 60 mg/dl (27.4 +/- 3.4 mumo...Continue Reading

Citations

Apr 3, 2008·Mayo Clinic Proceedings·Brenda G Fahy, Douglas B Coursin
Aug 1, 1996·Mayo Clinic Proceedings·C T Wass, W L Lanier
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·D S WarnerA M McAllister
Apr 1, 1991·Stroke; a Journal of Cerebral Circulation·R E Hofer, W L Lanier
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A TsujikawaY Ogura

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