The effects of treatment with drospirenone/ethinyl oestradiol alone or in combination with metformin on elastic properties of aorta in women with polycystic ovary syndrome

Clinical Endocrinology
Mehmet G KayaFahrettin Kelestimur

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous clinical condition. Oral contraceptive pills (OCPs) have conventionally been the mainstay of treatment for the amelioration of hyperandrogenism and regulation of menstrual cycles in women with PCOS. Metformin has beneficial effects on insulin resistance and endothelial functions. To our knowledge, the effect of metformin/OCP combination treatment on aortic stiffness has not been studied so far. The aim of this study was to investigate the effects of treatment with drospirenone/ethinyl oestradiol (E/E) alone or in combination with metformin on the elastic properties of the aorta in women with PCOS. Thirty-seven women with PCOS were enrolled in the study. The first treatment arm, which was treated with OCP alone, was described as the OCP group (19 patients, mean age: 23·2 ± 5·4); the other treatment arm, which was treated with OCP and metformin, was described as the combination group (18 patients, mean age: 23·0 ± 4·5). The elastic parameters of the aorta namely 'aortic strain', 'aortic distensibility', 'aortic diameter alteration' and 'aortic stiffness index' were calculated by the appropriate formulae. The hormonal profile, HOMA-IR score, basal insulin and glucose levels were ...Continue Reading

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Citations

Aug 30, 2014·BioMed Research International·Miodrag JanićMišo Sabovič
Mar 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mehmet Gungor KayaFahrettin Kelestimur
Jan 23, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P De RangoM Lenti
Jan 11, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefano PalombaCharles Sultan
May 23, 2015·Expert Opinion on Pharmacotherapy·Morena Luigia RoccaMichele Morelli
Jul 15, 2016·American Journal of Therapeutics·Ahmed Muzhir HusseinHanan K Helu

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