The Effects of Tryptophan on Everyday Interpersonal Encounters and Social Cognitions in Individuals with a Family History of Depression

The International Journal of Neuropsychopharmacology
Koen HogenelstMarije aan het Rot

Abstract

Individuals with a family history of depression show subtle abnormalities in the processing of social stimuli. This could negatively affect their interpersonal functioning and contribute to their depression risk. Repeated administration of the serotonin precursor tryptophan has previously been shown to increase agreeable behavior and reduce quarrelsome behavior in irritable people, who are also considered at risk for depression. To examine the effects of tryptophan on social functioning in individuals with a family history of depression, 40 men and women with at least one first-degree relative with depression received tryptophan (1g three times a day) and placebo for 14 days each in a double-blind crossover design and recorded their social behavior and mood during everyday interpersonal encounters. Participants also provided daily ratings of their positive and negative cognitions concerning their social functioning. Tryptophan improved mood. Unexpectedly, tryptophan increased quarrelsome behavior and reduced agreeable behavior, specifically during interactions at home. The behavioral effects of tryptophan were not moderated by mood or by the interaction partner. Negative social cognitions were lower when tryptophan was given se...Continue Reading

References

Oct 1, 1977·Archives of General Psychiatry·N C AndreasenG Winokur
Nov 1, 1984·Journal of Personality and Social Psychology·E Diener, R A Emmons
Jun 1, 1980·Journal of Abnormal Psychology·J E HokansonG C Landrum
Mar 21, 1998·The American Journal of Psychiatry·B KnutsonV I Reus
Jun 16, 1999·Journal of Abnormal Psychology·L Taylor, R E Ingram
Jun 1, 2000·The Journal of Clinical Psychiatry·R M HirschfeldM Bourgeois
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler
Jun 27, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D S MoskowitzS N Young
Jan 5, 2002·Behaviour Research and Therapy·Willem Van der Does
May 3, 2002·Molecular Psychiatry·A Frazer, S Benmansour
May 22, 2002·Psychopharmacology·Wai S Tse, Alyson J Bond
Oct 5, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frederik M van der VeenJeroen A J Schmitt
Jun 22, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marije aan het RotSimon N Young
Jul 17, 2008·The American Journal of Psychiatry·Aaron T Beck
Dec 2, 2009·Frontiers in Behavioral Neuroscience·Sietse F de BoerJaap M Koolhaas
Dec 10, 2009·Archives of General Psychiatry·Tony Z TangBenjamin Schalet
Jan 19, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alessandro SerrettiDiana De Ronchi
May 4, 2010·Journal of Personality·D S Moskowitz
Mar 8, 2011·Biological Psychiatry·Adriana FederDennis S Charney
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Dominik KiserJudith R Homberg
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul R AlbertLaurent Descarries
Jan 10, 2013·Annual Review of Clinical Psychology·Jennifer L HamesThomas E Joiner
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon N Young
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ardesheer TalatiSteven P Hamilton
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Catherine J Harmer, Philip J Cowen
Mar 19, 2013·Journal of Personality Assessment·Marije aan het RotD S Moskowitz
Sep 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zoe Y HsuSimon N Young
Nov 28, 2013·Journal of Psychiatry & Neuroscience : JPN·Simon N YoungMarije aan het Rot

❮ Previous
Next ❯

Citations

Mar 19, 2016·Neuroscience and Biobehavioral Reviews·Laura SteenbergenLorenza S Colzato
Oct 3, 2017·Psychological Medicine·A SchmidtS Borgwardt
Nov 21, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Małgorzata PająkMarianna Kańska
Jan 26, 2018·The Proceedings of the Nutrition Society·E L Gibson

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
D S MoskowitzS N Young
Advances in Experimental Medicine and Biology
D S MoskowitzSimon N Young
© 2022 Meta ULC. All rights reserved