The effects of tumor necrosis factor inhibitors on cardiovascular risk in rheumatoid arthritis

Current Pharmaceutical Design
Mike J L PetersMichael T Nurmohamed

Abstract

There is abundant evidence that rheumatoid arthritis (RA), a chronic inflammatory disorder, is associated with an increased risk for cardiovascular (CV) disease. While there may be several mechanisms contributing to a higher CV risk in RA patients, inflammation is considered to be the main cause explaining the excess CV burden. Inflammatory processes appear pivotal to the atherothrombotic process and are linked to endothelial dysfunction, fatty streak initiation and progression, deterioration of fatty streaks into (unstable) plaques, and plaque rupture. Moreover, systemic inflammation, through tumor necrosis factor (TNF) or related cytokines, appears to accelerate atherothrombosis either directly or via effects on conventional and novel CV risk factors, such as lipids and lipoproteins, blood pressure, haemostatic factors, and insulin resistance. New and highly specific therapeutic agents (TNF inhibitors) may significantly lower CV risk in RA. This review summarizes the evidence base supporting the notion that TNF inhibitors confer benefit CV disease risk in RA.

Citations

May 8, 2013·Zeitschrift für Rheumatologie·H Pieringer, U C Hoppe
Apr 2, 2013·Autoimmunity Reviews·Theodoros DimitroulasGeorge D Kitas
Mar 7, 2013·Der Internist·E Decker, U Müller-Ladner
Feb 6, 2016·Mayo Clinic Proceedings·Mariana GarciaSharon L Mulvagh
Jun 16, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Paulo J C LinPieter R Cullis
Jun 22, 2013·Seminars in Arthritis and Rheumatism·Sophie MavrogeniGeorge D Kitas
Dec 24, 2014·Nature Reviews. Cardiology·Megha PrasadAmir Lerman
Aug 2, 2013·Therapeutic Advances in Musculoskeletal Disease·Inge A M van den OeverMichael T Nurmohamed
Jul 24, 2013·Current Opinion in Allergy and Clinical Immunology·Valérie Gouilleux-GruartAlain Fischer
Oct 11, 2014·Clinical and Experimental Immunology·Y Chang, W Wei
Nov 10, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Ingrid VismanMichael Nurmohamed
May 22, 2021·Journal of Inflammation Research·George E FragoulisGeorge D Kitas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.