PMID: 15957626Jun 17, 2005Paper

The effects of two different anaesthesia techniques on bispectral index values and awareness during off-pump coronary artery bypass grafting

Journal of Clinical Monitoring and Computing
Azize BestasSuheyla Inalkac


The aim of this study was to evaluate Bispectral Index values and awareness during two different anaesthesia regimens (fentanyl-propofol and fentanyl-midazolam) in patients undergoing off-pump CABG surgery. Fifty patients were included in the study. Patients were premedicated with midazolam and were randomly divided into two groups. Anaesthesia was induced with fentanyl (7-15 microg/kg), with either propofol (2 - 2.5 mg/kg, Group I) or midazolam (0.1 - 0.3 mg/kg, Group II) and vecuronium (0.1 mg/kg). Anaesthesia was maintained with fentanyl (15 microg/kg/h) together with either propofol (6 mg/kg/h) or midazolam (0.1 mg/kg/h). Depth of anaesthesia was adjusted according to clinical signs and haemodynamic responses. The level of sedation was monitored with Bispectral index continuously, but these levels were not shown to the attending anaesthetist. Bispectral index values were recorded for nine phases. Twenty-four hours after the operation, the patients were interviewed to determine intraoperative awareness and recall. In all patients, Bispectral index values were found to decrease after induction (in Group I, p = 0.005, in Group II, p = 0.008) with the mean values remaining below 60 for all phases. The differences between the gr...Continue Reading


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Oct 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A A PhillipsE M Harrington
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Jun 13, 2002·Anaesthesia·R M HeamesD A Hett
Aug 3, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Seppo O-V RantaMarkku Hynynen

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Jun 18, 2014·The Cochrane Database of Systematic Reviews·Yodying PunjasawadwongNutchanart Bunchungmongkol
Sep 11, 2014·Anaesthesia·T M CookUNKNOWN Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland
Sep 27, 2019·The Cochrane Database of Systematic Reviews·Sharon R LewisYodying Punjasawadwong
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