The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis

The British Journal of Dermatology
H SigmundsdottirH Valdimarsson

Abstract

T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte-associated antigen (CLA), compared with < 20% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis. To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes. Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment. A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen-4alpha by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T-cell expression of intercellular adhesion molecule-1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens. UVB treatment is associated with a marked reduction in the expression of skin-homi...Continue Reading

References

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Citations

May 13, 2005·Archives of Dermatological Research·Hekla SigmundsdottirHelgi Valdimarsson
Apr 13, 2005·Acta Dermato-venereologica·H Jorn BovenschenPeter C M van de Kerkhof
Jan 29, 2011·The British Journal of Dermatology·E SøylandM S Nenseter
Dec 24, 2005·The Journal of Investigative Dermatology·Anne WetzelAnja Saalbach
Oct 2, 2007·Dermatologic Clinics·Hagit Matz
Apr 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C AntúnezM Blanca
Jul 21, 2009·Photodermatology, Photoimmunology & Photomedicine·Lill T N NilsenAnne L Krogstad
Jan 27, 2007·Photodermatology, Photoimmunology & Photomedicine·Engin Sezer, Ilker Etikan
Jan 5, 2011·Photodermatology, Photoimmunology & Photomedicine·Daniela Pereira AnteloJosé Marcos Telles Cunha
Jul 19, 2005·Journal of Dermatological Science·Péter HollóAttila Horváth
Jun 18, 2016·Journal of Photochemistry and Photobiology. B, Biology·Aleksandra Batycka-BaranJoerg C Prinz

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