The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects

Metabolism: Clinical and Experimental
Min Ho ChaYoosik Yoon

Abstract

Responses to energy restriction tend to vary within the population because of genetic differences. In this study, we have genotyped 6 uncoupling protein 3 (UCP-3) polymorphisms (-55C/T, Int2-143G/C, Tyr99Tyr, Int3-47G/A, Int4-498C/T, and Tyr210Tyr) among 214 overweight Korean female subjects recruited from an obesity clinic. Three major haplotypes, identified with frequencies in excess of 0.04, were constructed from 6 single nucleotide polymorphisms. Association studies were then undertaken, involving the measurement of anthropometric characteristics and body composition both before and after 1 month of a energy-restriction regimen. At baseline, haplotype 1 (ht1) [CGTACC] was associated with elevated anthropometric characteristics, including body weight, waist-hip ratio, and body mass index, as well as body components, including body fat mass and body fat-free mass. After the completion of the 1-month weight control program, which involved a very low-energy (2900 kJ/d) diet, we analyzed the outcomes according to the UCP-3 genetic polymorphisms. Among the 3 principal haplotypes, ht1 [CGTACC] was significantly associated with an increased reduction in body weight, in the codominant (P=.022), dominant (P=.016), and recessive (P=.0...Continue Reading

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Citations

May 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Douglas C Wallace
Nov 21, 2008·Nutrition Reviews·Lu Qi, Young Ae Cho
Jul 6, 2010·Ageing Research Reviews·Gregory J Tranah
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Jun 5, 2007·Biochemical and Biophysical Research Communications·Yoosik YoonHyoung Doo Shin
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Sep 22, 2009·Arquivos brasileiros de endocrinologia e metabologia·Thais SteemburgoJosé Alfredo Martínez

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