The Effects of Valsartan and Amlodipine on the Levels of Irisin, Adropin, and Perilipin

Clinical Laboratory
Huseyin Tugrul ÇelikRamazan Yigitoglu

Abstract

Hypertension and obesity are two major threats for public health. Up to the present, antihypertensive medications have been used to lower blood pressure, which seem to provide a better life with lower morbidity and mortality rates. Their effect on etiopathogenesis of hypertension is now an area of developing research. The association between hypertension and obesity also suggests the link between antihypertensive agents and energy hemostasis. We aimed to investigate the effects of antihypertensive treatment on the irisin, adropin, and perilipin levels in patients with essential hypertension and to compare them with healthy volunteers in terms of their effect on energy hemostasis. In total, 85 newly diagnosed patients with untreated essential hypertension were admitted to the outpatient clinic. Patients were randomized to one of the following treatment protocols: amlodipine or valsartan for a 12 week period. 42 patients were randomized into the valsartan group and 43 patients into the amlodipine group. Serum perilipin, irisin, and adropin levels were measured before and after drug treatment by ELISA kits. We discovered that the hypertensive patients have lower levels of perilipin and higher levels of adropin compared with the co...Continue Reading

Citations

May 28, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken ChenDachun Yang
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariami JasaszwiliMarek Skrzypski
Nov 21, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Bellina A S Mushala, Iain Scott
Oct 9, 2021·Journal of the American Heart Association·Jinjuan FuJian Yang

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