Nov 1, 2005

The effects of vanadium treatment on bone in diabetic and non-diabetic rats

Bone
D M FacchiniM D Grynpas

Abstract

Vanadium-based drugs lower glucose by enhancing the effects of insulin. Oral vanadium drugs are being tested for the treatment of diabetes. Vanadium accumulates in bone, though it is not known if incorporated vanadium affects bone quality. Nine- to 12-month-old control and streptozotocin-induced diabetic female Wistar rats were given bis(ethylmaltolato)oxovanadium(IV) (BEOV), a vanadium-based anti-diabetic drug, in drinking water for 12 weeks. Non-diabetic rats received 0, 0.25 or 0.75 mg/ml BEOV. Groups of diabetic rats were either untreated or treated with 0.25-0.75 mg/ml BEOV as necessary to lower blood glucose in each rat. In diabetic rats, this resulted in a Controlled Glucose group, simulating relatively well-managed diabetes, and an Uncontrolled Glucose group, simulating poorly managed diabetes. Plasma insulin, glucose and triglyceride assays assessed the diabetic state. Bone mineral density (BMD), mechanical testing, mineral assessment and histomorphometry measured the effects of diabetes on bone and the effects of BEOV on non-diabetic and diabetic bone. Diabetes decreased plasma insulin and increased plasma glucose and triglycerides. In bone, diabetes decreased BMD, strength, mineralization, bone crystal length, and bo...Continue Reading

  • References32
  • Citations42
  • References32
  • Citations42

Citations

Mentioned in this Paper

Diaphyses
Neuro-Oncological Ventral Antigen 2
Calcium [EPC]
Bone Resorption
Crystal - Body Material
Torsion (Malposition)
Trabecular Substance of Bone
Decompression Sickness
Fluoride Measurement
Calcium

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