PMID: 6974894Jan 1, 1980Paper

The effects of variable age-of-onset and diagnostic criteria on the estimates of linkage: an example using manic-depressive illness and color blindness

Social Biology
L A Morton, K K Kidd

Abstract

Three pedigrees were selected from the literature for their compatibility with the hypothesis of linkage between the X-chromosome marker color blindness and bipolar affective disorder. We compared the results of linkage analyses of these pedigrees when both penetrance function and diagnostic classification were varied. The analyses show that the incorporation of age-of-onset information into a penetrance function significantly increased the evidence for linkage. In addition, assumptions about diagnostic classification affected the lod scores. These results demonstrate the need for careful consideration of diagnostic criteria and variable age-of-onset when pursuing linkage analysis of complex traits.

References

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Dec 1, 1979·Archives of General Psychiatry·J MendlewiczH M Van Praag
Jan 1, 1977·Journal of Psychiatric Research·E S Gershon, W E Bunney
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Citations

Nov 26, 1981·The New England Journal of Medicine·S Matthysse, K K Kidd
Jan 1, 1990·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M RutterE Simonoff
May 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·D C Watt
Apr 1, 1987·Acta Psychiatrica Scandinavica·E SmeraldiC Perris
Sep 1, 1988·Journal of Medical Genetics·L A FarrerP M Conneally
Jan 1, 1989·Genetic Epidemiology·R A Price
Jan 1, 1982·Journal of Psychiatric Research·E SmeraldiA Morabito

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