PMID: 15394075Dec 1, 1949Paper

The effects of various horse serum fractions in producing cardiovascular and renal lesions in rabbits

The Journal of Experimental Medicine
R W WISSLERJ B LESH

Abstract

Five groups of 10 rabbits each were injected intravenously 2 times at 15 day intervals with either whole horse serum or one of its cold alcohol-precipitated fractions. Suitable serological and general observations were made at appropriate intervals before and after each injection. All animals were sacrificed on the 22nd day of the experiment. A study of the antemortem and pathological findings led to the following conclusions. 1. Allergie arteritis, valvulitis, and to a lesser degree, focal pericarditis, Aschoff-like nodules, and glomerulitis can be produced by several of the cold alcohol-precipitated fractions of horse serum as well as by whole serum. 2. Most of the acute arteritis was seen in rabbits receiving fraction V (albumin). These rabbits showed the largest amounts of circulating antigen, low antibody titers, low tissue sensitivity, and slight elevation in sedimentation rate and temperature. 3. There was a high incidence of chronic arteritis in the rabbits receiving fraction III which is almost devoid of albumin, suggesting that the alpha and beta globulins in addition to albumin may produce arteritis. 4. A state most nearly resembling that of acute rheumatic fever was produced by either fractions III or IV-3,4 (alpha ...Continue Reading

References

Jan 1, 1949·The Journal of Experimental Medicine·W E EHRICHC FORMAN
May 1, 1949·The Journal of Experimental Medicine·R H MORE, D WAUGH
Dec 1, 1913·The Journal of Experimental Medicine·W T Longcope
Jan 31, 1932·The Journal of Experimental Medicine·E W Todd
Sep 30, 1933·The Journal of Experimental Medicine·W S Tillett, R L Garner
May 31, 1947·The Journal of Experimental Medicine·C V Hawn, C A Janeway

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Citations

Oct 1, 1951·The Journal of Pathology and Bacteriology·T CRAWFORD, J R NASSIM
Jun 15, 1955·Proceedings of the National Academy of Sciences of the United States of America·R W Lippman
Jun 1, 1952·The Journal of Experimental Medicine·D WAUGH, R H MORE
Dec 16, 1957·Annals of the New York Academy of Sciences·R W WISSLER, M H FLAX
Apr 1, 1955·Journal of Chronic Diseases·J A LUETSCHERR H CURTIS
Apr 1, 1989·Kidney International·P J Hoedemaeker, J J Weening
Jan 1, 1962·Acta Rheumatologica Scandinavica·G NORLIN
Jan 1, 1954·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·H OTTO
Jun 30, 1960·Annals of the New York Academy of Sciences·D F CHAR, B M WAGNER

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