The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children

The Journal of Clinical Endocrinology and Metabolism
Michael B ZimmermannT Torresani

Abstract

In developing countries, children are at high risk for both the iodine deficiency disorders (IDD) and vitamin A deficiency (VAD). The study aim was to determine the effects of VAD and vitamin A (VA) supplementation on thyroid function in an area of endemic goiter. In a double-blind, randomized, 10-month trial, Moroccan children with IDD and VAD (n = 138) were given iodized salt and either VA (200,000 IU) or placebo at 0 and 5 months. At 0, 5, and 10 months, measurements of VA status and thyroid function were made. At baseline, increasing VAD severity was a predictor of greater thyroid volume and higher concentrations of TSH and thyroglobulin (P < 0.001). In children with VAD, the odds ratio for goiter was 6.51 (95% confidence interval, 2.94, 14.41). VAD severity was also a strong predictor of higher concentrations of total T(4) (P < 0.001); the odds ratio for hypothyroidism in VAD was 0.06 (95% confidence interval, 0.03, 0.14). During the intervention, mean thyroglobulin, median TSH, and the goiter rate significantly decreased in the VA-treated group compared with those in the placebo group (P < 0.01). The findings indicate that VAD in severely IDD-affected children increases TSH stimulation and thyroid size and reduces the ris...Continue Reading

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Citations

Oct 18, 2006·Thyroid : Official Journal of the American Thyroid Association·Ralf BiebingerMichael B Zimmermann
Mar 14, 2012·Thyroid : Official Journal of the American Thyroid Association·Hossien DelshadFereidoun Azizi
Apr 11, 2006·Annual Review of Nutrition·Michael B Zimmermann
Jan 22, 2009·Journal of Nutritional Science and Vitaminology·Mansour SiavashRoya Kelishadi
Feb 23, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Sonja Y Hess
May 20, 2006·Hormone Research·Mansour Siavash DastjerdiMohammad Hassan Moaddab
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Dec 31, 2008·International Journal of Food Sciences and Nutrition·Mahin HashemipourNavid Koleini
Jan 17, 2019·Journal, Genetic Engineering & Biotechnology·Salwa Refat El-ZayatAzza Abd El-Shaheed
Feb 5, 2013·Journal of the American College of Nutrition·Mahdieh Abbasalizad FarhangiAli Akbar Saboor-Yaraghi
May 23, 2009·Endocrine Reviews·Michael B Zimmermann
Oct 9, 2007·The American Journal of Clinical Nutrition·Michael B ZimmermannXikombiso Mbhenyane
Feb 23, 2017·Environmental Geochemistry and Health·Masoumeh MohammadiMehdi Hedayati

Related Concepts

Prevalence Studies
Double-Blind Method
Goiter
Thyroid Gland
Thyroid Hormones
Aquasol A
Vitamin A Deficiency
Nutraceuticals

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