The effects of vitamin D supplementation on proatherogenic inflammatory markers and carotid intima media thickness in subjects with metabolic syndrome: a randomized double-blind placebo-controlled clinical trial

Endocrine
S SalekzamaniB P Gargari

Abstract

Metabolic syndrome may predispose to cardiovascular diseases. Since, in recent studies, vitamin D is advocated for cardioprotective roles, this study was designed to investigate the effects of vitamin D supplementation on proatherogenic inflammatory markers and common carotid intima media thickness in subjects with metabolic syndrome. This randomized double blind clinical trial was conducted in Tabriz, Iran. Eligible subjects (n = 80) with metabolic syndrome were recruited thorough advertisement and randomized to receive either vitamin D (50,000 IU/week) or matching placebo for 16 weeks. Interlukin-6, high sensitivity C-reactive protein, vascular cell adhesion molecule-1, E-selectin, and common carotid intima media thickness were measured at the beginning and end of the study. The study was registered at http://www.irct.ir (code: IRCT201409033140N14). Sixteen weeks supplementation with vitamin D increased median of serum 25-hydroxy vitamin D [25(OH)D] and mean calcium levels (p < 0.001) in the intervention group. There was also a significant difference in parathyroid hormone level at the end of the study (p < 0.001). Vitamin D treatment reduced IL-6 level after 16 weeks (p = 0.027). Compared to baseline, vascular cell adhesion ...Continue Reading

References

May 26, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michael AviramTony Hayek
Nov 13, 2004·BMC Medical Research Methodology·Mahmood Saghaei
Dec 20, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E A KaperonisV G Papavassiliou
May 21, 2008·European Journal of Clinical Investigation·E IngelssonL Lind
Jun 11, 2008·Archives of Internal Medicine·Edward GiovannucciEric B Rimm
Aug 5, 2009·Thrombosis and Haemostasis·Harald SchuettBernhard Schieffer
Dec 2, 2010·The Journal of Clinical Endocrinology and Metabolism·A Catharine RossSue A Shapses
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Jul 2, 2011·Stroke; a Journal of Cerebral Circulation·Angela L CarrelliShonni J Silverberg
Jul 22, 2011·The New England Journal of Medicine·Joseph F PolakRalph B D'Agostino
Dec 21, 2011·Nephrology·Magdalene M AssimonDarius L Mason
Feb 22, 2012·Diabetes/metabolism Research and Reviews·Sakineh Shab-BidarA'azam Gharavi
Jul 20, 2012·European Journal of Preventive Cardiology·Pierre-Jean TouboulHester den Ruijter
Mar 26, 2013·Journal of Clinical Biochemistry and Nutrition·Misung KimCheongmin Sohn
Aug 28, 2013·Hämostaseologie·M Rohla, T W Weiss
Dec 4, 2013·Circulation·Eva KassiAthanasios G Papavassiliou
Sep 27, 2014·Endocrine·Roger Bouillon, Lieve Verlinden
May 2, 2015·Endocrine·Giovanna MuscogiuriAnnamaria Colao
May 18, 2016·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Udenze Ifeoma ChristianaAjie I Obiefuna

❮ Previous
Next ❯

Citations

Oct 10, 2018·Ultrasound Quarterly·Elçin AydinMuhteşem Ağildere
Aug 9, 2017·Annals of Medicine·Cesare R SirtoriMassimiliano Ruscica
Aug 4, 2018·Indian Journal of Clinical Biochemistry : IJCB·Farahnaz AskarianNadereh Rahtchizadeh
Aug 9, 2019·Journal of Mid-life Health·Zinat GhanbariZatollah Asemi
Feb 13, 2021·Biomedicines·Andrei Mihai SurduGabriel Cismaru
Jun 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh DashtiAhmad Esmaillzadeh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.