The Effects of Vitamin E from Elaeis guineensis (Oil Palm) in a Rat Model of Bone Loss Due to Metabolic Syndrome

International Journal of Environmental Research and Public Health
Sok Kuan WongSoelaiman Ima-Nirwana

Abstract

The beneficial effects of vitamin E in improving components of MetS or bone loss have been established. This study aimed to investigate the potential of palm vitamin E (PVE) as a single agent, targeting MetS and bone loss concurrently, using a MetS animal model. Twelve-week-old male Wistar rats were divided into five groups. The baseline group was sacrificed upon arrival. The normal group was given standard rat chow. The remaining three groups were fed with high-carbohydrate high-fat (HCHF) diet and treated with tocopherol-stripped corn oil (vehicle), 60 mg/kg or 100 mg/kg PVE. At the end of the study, the rats were evaluated for MetS parameters and bone density. After euthanasia, blood and femurs were harvested for the evaluation of lipid profile, bone histomorphometric analysis, and remodeling markers. PVE improved blood pressure, glycemic status, and lipid profile; increased osteoblast surface, osteoid surface, bone volume, and trabecular thickness, as well as decreased eroded surface and single-labeled surface. Administration of PVE also significantly reduced leptin level in the HCHF rats. PVE is a potential agent in concurrently preventing MetS and protecting bone loss. This may be, in part, achieved by reducing the leptin...Continue Reading

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Citations

Mar 27, 2019·International Journal of Molecular Sciences·Sok Kuan WongSoelaiman Ima-Nirwana
Mar 21, 2019·International Journal of Molecular Sciences·Kok-Yong Chin, Soelaiman Ima-Nirwana
Sep 12, 2019·International Journal of Environmental Research and Public Health·Sok Kuan WongSoelaiman Ima-Nirwana
Oct 3, 2020·Antioxidants·Melanie ZieglerKarlheinz Peter
Nov 26, 2020·Drug Design, Development and Therapy·Sophia Ogechi EkeukuKok-Yong Chin

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay

Software Mentioned

MediaCybernetics Image Pro - Plus
Statistical Package for Social Sciences ( SPSS )
Small Analysis

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