PMID: 16628063Apr 22, 2006Paper

The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humans

Journal of Neurosurgical Anesthesiology
Kenichi SekimotoFumio Goto

Abstract

The aim of the present study was to compare the influence of volatile anesthetics on transcranial motor-evoked potentials (tcMEP) in humans anesthetized with propofol/fentanyl/nitrous oxide and on partial neuromuscular blockade (NMB). The authors studied 35 ASA I and II patients who were undergoing elective craniotomy and brain tumor resection. The patients were randomized to one of three groups to receive halothane (HAL), isoflurane (ISO), or sevoflurane (SEV). Anesthetic depth was initially adjusted using the bispectral index to 40+/-5, and NMB was adjusted to 40%-50% of one twitch of train of four (T1) after recovery from intubation. MEPs with train of five square-wave pulses were elicited using screw electrodes placed in the skull over C3-C4. After craniotomy, the inhalational agent was introduced at 0.5 MAC and then 1.0 MAC (20 minutes each), and the effects on MEPs, NMB, and hemodynamic variables were studied. A decrease in BIS and systolic blood pressure was observed with all agents. Both SEV and ISO at 1.0 MAC significantly decreased train-of-four ratio from 38.4+/-18.1 at control to 19.0+/-9.7 and from 35.3+/-12.4 to 26.1+/-13.7, respectively (P<0.001), but not HAL at 1.0 MAC. The amplitudes of tcMEPs were significantl...Continue Reading

References

Jun 1, 1990·Neurosurgery·S S HaghighiG R Kracke
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Citations

Jul 11, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Thomas N PajewskiLawrence H Phillips
Sep 28, 2012·Journal of Clinical Monitoring and Computing·Tod B Sloan
Feb 5, 2014·Anesthesiology Clinics·Chris D Glover, Nicholas P Carling
Jan 2, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Tod B SloanAntoun Koht
Sep 22, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·C Dahyot-FizelierB Debaene
Nov 17, 2009·Journal of the Neurological Sciences·Sung Ho JangSu Min Son
Mar 21, 2009·Neurological Research·Gerald A MatchettJohn H Zhang
Dec 3, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marshall F WilkinsonAnthony M Kaufmann
May 14, 2016·Journal of Neurosurgery·Marshall F WilkinsonAnthony M Kaufmann
Sep 9, 2006·Current Opinion in Anaesthesiology·Kristin Engelhard, Christian Werner
Apr 7, 2007·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Jan 6, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael G VitaleDavid P Roye
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Sanjib D AdhikaryPrathap Tharyan
May 28, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lashmi VenkatraghavanAtul Prabhu
Jul 11, 2007·Current Opinion in Anaesthesiology

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