PMID: 9535145Apr 16, 1998Paper

The effects of voluntary running on cardiac mass and aortic compliance in Wistar-Kyoto and spontaneously hypertensive rats

Journal of Hypertension
B A KingwellA M Dart

Abstract

To investigate the effects of voluntary running exercise from 4-20 weeks of age on aortic compliance in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). For each species we made comparisons between rats housed with an exercise wheel locked (10 rats) and unlocked (10 rats). Rats were killed using CO2 asphyxia and the aorta and heart of each rat were rapidly removed. The heart was dissected and weighed. A 4 mm descending proximal aortic ring was mounted on wires in an organ bath for determination of static compliance from the slope of the diameter-pressure relationship derived using Laplace's equation. During the final 2 weeks of training WKY rats ran an average of 7.9 +/- 1.0 km/24 h compared with 1.0 +/- 0.2 km/24 h for SHR. Body weights of WKY rats and SHR and of animals housed with locked and unlocked exercise wheels did not differ. The septum, left ventricle and total heart weights and left ventricular:body weight ratios of sedentary SHR were greater than those of sedentary WKY rats. Trained WKY rats had significantly higher atrial, left and right ventricular and total heart weights and left ventricular:body weight ratios than did untrained WKY rats. Aortic compliance was higher in trained than it was in se...Continue Reading

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Citations

Dec 7, 2010·Cancer Chemotherapy and Pharmacology·David S HydockReid Hayward
Nov 16, 2007·Basic Research in Cardiology·Judith Christina EiseleChristian Mühlfeld
Jan 17, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Antonello D'AndreaMaria Giovanna Russo
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Bronwyn A Kingwell
May 9, 2006·Medicine and Science in Sports and Exercise·Julien BoissierePierre Bonnet
Jul 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Masaki MizunoScott A Smith
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·David S HydockReid Hayward
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
Dec 8, 2017·Journal of Physiological Anthropology·Takafumi Maeda
Jul 19, 2001·Annals of the New York Academy of Sciences·E M KriegerC E Negrão
Apr 12, 2001·Journal of Applied Physiology·D L AllenL A Leinwand

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