PMID: 6405784May 5, 1983Paper

The effects of weak acids on potassium uptake by Escherichia coli K-12 inhibition by low cytoplasmic pH

Biochimica Et Biophysica Acta
Evert P Bakker, W E Mangerich

Abstract

The activity of the Escherichia coli K+ transport system TrkA was measured as a function of the cytoplasmic pH of the cell. For this purpose, pHin was decreased by the addition of the weak acids acetic acid, benzoic acid or salicylic acid to K+-depleted cells. Under these conditions, the initial rate of K+ uptake decreased strongly with pHin, and was almost independent of the acid used. This inhibition was due to a strong decrease in the Vmax for K+ uptake, which indicates that low cytoplasmic pH inactivates the TrkA K+ uptake system. The relevance of this inhibition for growth and metabolism at low pHin is discussed.

References

Nov 1, 1975·Analytical Biochemistry·G A KimmichJ S Brand
Mar 1, 1976·The Journal of General Physiology·D B RhoadsW Epstein
Feb 21, 1978·Biochemistry·S Schuldiner, H Fishkes
Aug 23, 1979·Biochimica Et Biophysica Acta·E KomorW Tanner
Dec 17, 1973·European Journal of Biochemistry·E Padan, H Rottenberg
Jan 1, 1972·The Journal of Membrane Biology·F M Harold, D Papineau
Oct 1, 1974·The Biochemical Journal·I C West, P Mitchell
Nov 1, 1971·Journal of Bacteriology·W Epstein, B S Kim
Sep 1, 1980·Journal of Bacteriology·H Kobayashi, T Unemoto
Jun 15, 1980·The Biochemical Journal·L M Russell, H Rosenberg
Dec 1, 1981·Biochimica Et Biophysica Acta·E PadanS Schuldiner
Jun 1, 1982·Journal of Bacteriology·K J HellingwerfW N Konings
Apr 19, 1982·FEBS Letters·E P Bakker, W E Mangerich
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B Setlow, P Setlow
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J K BartonR G Shulman
Mar 1, 1981·Journal of Bacteriology·M Kihara, R M Macnab
Sep 15, 1981·The Biochemical Journal·R G Kroll, I R Booth
Nov 1, 1963·The Journal of General Physiology·S G SCHULTZA K SOLOMON

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Citations

Jul 5, 2015·Applied Microbiology and Biotechnology·Janja TrčekLaura R Jarboe
Jun 22, 2011·Microbiological Research·Galina SmirnovaOleg Oktyabrsky
Mar 15, 1989·European Journal of Biochemistry·A Witte, W Lubitz
Jan 25, 2008·Nature·Koushik PaulKelly T Hughes
May 12, 2006·The Journal of Biological Chemistry·Martha V RadchenkoTatsunosuke Nakamura
Apr 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T M RodelaP A Wright
Oct 19, 2019·The Journal of General Physiology·Vedrana MikuševićInga Hänelt
Jul 6, 1988·Biochimica Et Biophysica Acta·A Z KhachatryanS M Martirosov
Dec 1, 1985·Microbiological Reviews·I R Booth
Jun 14, 2003·Biochemical and Biophysical Research Communications·Karine BagramyanArmen Trchounian
Dec 1, 1987·Microbiological Reviews·B PoolmanW N Konings
Aug 1, 1996·Applied and Environmental Microbiology·H J HeipieperJ de Bont

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