The effects of zinc deficiency and supplementation on lipid peroxidation in bone tissue of ovariectomized rats

Toxicology
Abdulkerim Kasim BaltaciEsma Oztekin

Abstract

This study aims at investigating how zinc deficiency and zinc application affect lipid peroxidation in bone tissue of ovariectomized rats. The study included 40 adult female rats of Sprague-Dawley species. Group 1 (n = 10): control group were fed with normal diet. Group 2 (n = 10): the group fed with normal diet after being ovariectomized. Group 3 (n = 10): the group fed with zinc-deficient diet for 6 weeks after ovariectomy. Group 4 (n = 10): the group which was given intraperitoneal zinc (3 mg/kg day zinc) in addition to normal diet for 6 weeks after ovariectomy. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in erythrocyte, plasma and bone tissue. Group 3 had the highest plasma MDA levels compared to Groups 1, 2 and 4 (P < 0.05). These values were higher in Group 2 than in Groups 1 and 4 (P < 0.05). Bone and plasma MDA levels in Groups 1 and 4 were not different. Bone and erythrocyte GSH levels in Group 4 were higher than those in all other groups (P < 0.05). The lowest levels of bone and erythrocyte GSH levels were observed in Group 3 (P < 0.05). These values were higher in Group 2 when compared to those in Groups 1 and 3 (P < 0.05). This study demonstrate that zinc deficiency increased bone tissue damag...Continue Reading

References

Jun 1, 1993·Diabetes Research and Clinical Practice·H FushimiY Okazaki
Aug 1, 1993·Journal of the American College of Nutrition·P D Saltman, L G Strause
Jun 1, 1996·Obstetrics and Gynecology·M HerzbergY Frenkel
Aug 26, 2000·Journal of Bone and Mineral Metabolism·Z J Ma, M Yamaguchi
Feb 24, 2001·Journal of the American College of Nutrition·J Z Ilich, J E Kerstetter
Jul 13, 2001·Menopause : the Journal of the North American Menopause Society·M A Gómez-ZubeldiaJ C Millán
Jul 23, 2002·The Proceedings of the Nutrition Society·Nicola M LoweMalcolm J Jackson

❮ Previous
Next ❯

Citations

Dec 17, 2009·Acta Veterinaria Scandinavica·Monika MartiniakováPeter Chrenek
Mar 25, 2010·International Journal of Colorectal Disease·A M El-Tawil
Apr 4, 2008·International Journal of Radiation Biology·Amit KumarKaushala Prasad Mishra
Mar 5, 2016·Bioscience, Biotechnology, and Biochemistry·Takako SuzukiKazuharu Suzuki
Oct 14, 2008·Chemico-biological Interactions·Joanna RogalskaJanina Moniuszko-Jakoniuk
Jul 5, 2008·Basic & Clinical Pharmacology & Toxicology·Sandra ManiamIma Nirwana Soelaiman
May 7, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ahmad Nazrun ShuidIma Nirwana Soelaiman
Aug 16, 2017·Biological Trace Element Research·Abdulkerim Kasim BaltaciRasim Mogulkoc
Mar 21, 2020·Archives of Physiology and Biochemistry·Hajer JdidiAbdelfattah El Feki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.