The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants

Aquatic Toxicology
Halina I FalfushynskaO B Stoliar

Abstract

Nanoparticle toxicity is a growing concern in freshwater habitats. However, understanding of the nanoparticle effects on aquatic organisms is impeded by the lack of the studies of the nanoparticles effects in the environmentally relevant context of multiple stress exposures. Zinc oxide nanoparticles (n-ZnO) are widely used metal-based nanoparticles in electronics and personal care products that accumulate in aquatic environments from multiple non-point sources. In this study, we evaluated the effects of n-ZnO in a model organism, a mussel Unio tumidus, and the potential modulation of these effects by common co-occurring environmental stressors. Male U. tumidus were exposed for 14 days to n-ZnO (3.1 μM), Zn(2+) (3.1 μM), Ca-channel blocker nifedipine (Nfd 10 μM), combinations of n-ZnO and Nfd or n-ZnO and thiocarbamate fungicide Tattoo (Ta, 91 μg L(-1)) at 18 °C, and n-ZnO at 25 °C (n-ZnO+t°). Total and metallothionein-bound Zn levels as well as levels of metallothioneins (MT), cellular stress responses and cytotoxicity biomarkers were assessed in the mussels. The key biomarkers that showed differential responses to different single and combined stressors in this study were activities of caspase-3 and lysosomal cathepsin D, as w...Continue Reading

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Citations

May 20, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Halina FalfushynskaRostyslav Stoika
May 11, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·François GagnéKevin J Wilkinson
Apr 23, 2016·Environmental Science and Pollution Research International·Ilaria MarisaMaria Gabriella Marin
May 22, 2016·The Journal of Experimental Biology·Timothy A CrombieDavid Julian
May 16, 2020·Bulletin of Environmental Contamination and Toxicology·Vira KhomaOksana Stoliar
Oct 13, 2018·The Science of the Total Environment·Halina I FalfushynskaInna M Sokolova
Apr 4, 2021·International Journal of Molecular Sciences·Ghasem RashidianCaterina Faggio

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