PMID: 6538912Mar 1, 1984Paper

The effects on beagles of long-term administration of 20% Travamulsion fat emulsion

JPEN. Journal of Parenteral and Enteral Nutrition
R S IzzoN Leissing

Abstract

The tolerance of 20% Travamulsion intravenous fat emulsion (Travenol Laboratories, Inc., Deerfield, IL) was studied using male beagle dogs. Physiologic (0.9%) saline, USP, was used as the control, and 10% Travamulsion Intravenous fat emulsion (Travenol Laboratories) as the reference article. The 20 and 10% emulsions were administered intravenously to each of eight animals for 91 days at 20 and 40 ml/kg/day, respectively. These dosages were administered over 4 hr and they correspond to approximately 4 g of lipid as soybean oil per kilogram of body weight. The saline was administered to eight animals at 40 ml/kg/day. On day 92, one-half of the animals in each group were necropsied. The remaining dogs were observed and necropsied on day 122. Toxicity was assessed on animal survival; changes in body weight, urinalysis, and hematologic, and serum biochemical analyses; ophthalmologic examination; gross pathology; and histopathology. The results obtained for the 20% Travamulsion fat emulsion correlated well with those for the 10% Travamulsion fat emulsion. The emulsions were well tolerated and all animals survived and gained weight. The 20% Travamulsion fat emulsion administered provided about 45% of the total caloric requirement of t...Continue Reading

References

Jun 1, 1979·JAMA : the Journal of the American Medical Association·K D LindorM A Hirschkorn
May 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·R S IzzoS Larcker
Sep 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·R S IzzoN Leissing
Jan 1, 1964·The American Journal of Clinical Nutrition·B EDGRENA WRETLIND
Jan 1, 1965·The American Journal of Clinical Nutrition·S W THOMPSONI COHN
Jan 1, 1965·The American Journal of Clinical Nutrition·A R VELAI COHN

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Citations

Jan 1, 1996·Progress in Lipid Research·A C BachA Frey
Aug 23, 2008·Drug Development and Industrial Pharmacy·Elise BracqMichel Guerbet

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