The effects on cardio-respiratory and acid-base variables of the anaesthetic alfaxalone in a 2-hydroxypropyl-β-cyclodextrin (HPCD) formulation in sheep

The Veterinary Journal
A AndaluzFélix García

Abstract

The objective of this study was to determine the pharmacodynamic effects in sheep of the anaesthetic alfaxalone in a 2-hydroxypropyl-β-cyclodextrin formulation. Seven Ripollesa sheep, weighing 43.0±6.6 kg, were used in the study. Twenty-four hours after instrumentation, the sheep were anesthetised with alfaxalone (2 mg/kg bodyweight IV) in cyclodextrin. Heart rate, arterial blood pressure, respiratory rate and arterial blood gases were recorded. Alfaxalone administration resulted in minimal cardio-respiratory depression. Time to standing from anaesthesia was 22.0±10.6 min. Apnoea was not observed in any of the sheep. Significant differences from baseline were not observed in respiratory rate or arterial blood pressure. Heart rate increased significantly (P<0.05) immediately after administration, returning to control values at 20 min. The calculated haemoglobin saturation (SO2) decreased significantly during the first 15 min after alfaxalone administration. The arterial pH decreased significantly during the first 30 min of the study, although no significant differences from basal values were observed in the arterial partial pressure of carbon dioxide (PaCO2). The results showed that alfaxalone in 2-hydroxypropyl-β-cyclodextrin a...Continue Reading

References

Sep 1, 1990·British Journal of Anaesthesia·W B RuncimanD G Selby
Jun 29, 2005·The Veterinary Journal·A AndaluzF García
Jun 13, 2006·Veterinary Anaesthesia and Analgesia·Pierre J FerréHervé P Lefebvre
Sep 17, 2008·Veterinary Anaesthesia and Analgesia·William MuirTed Whittem
Jan 6, 2009·Veterinary Anaesthesia and Analgesia·William MuirTed Whittem
Jan 27, 2009·The Veterinary Record·M K MarshS K Maloney

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Citations

Jul 9, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Silvia Villaverde-MorcilloIgnacio A Gómez de Segura
May 31, 2013·Journal of the South African Veterinary Association·T Brighton Dzikiti
Sep 14, 2018·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Maggie WilliamsÅsa Fahlman
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Mahmoud M AbouelfetouhYi Ding
May 24, 2021·Veterinary Anaesthesia and Analgesia·Molly PattersonKathreen Ruckstuhl
May 20, 2014·Veterinary Anaesthesia and Analgesia·Ana M del ÁlamoMark E Payton

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