Abstract
The objective of this study was to determine the pharmacodynamic effects in sheep of the anaesthetic alfaxalone in a 2-hydroxypropyl-β-cyclodextrin formulation. Seven Ripollesa sheep, weighing 43.0±6.6 kg, were used in the study. Twenty-four hours after instrumentation, the sheep were anesthetised with alfaxalone (2 mg/kg bodyweight IV) in cyclodextrin. Heart rate, arterial blood pressure, respiratory rate and arterial blood gases were recorded. Alfaxalone administration resulted in minimal cardio-respiratory depression. Time to standing from anaesthesia was 22.0±10.6 min. Apnoea was not observed in any of the sheep. Significant differences from baseline were not observed in respiratory rate or arterial blood pressure. Heart rate increased significantly (P<0.05) immediately after administration, returning to control values at 20 min. The calculated haemoglobin saturation (SO2) decreased significantly during the first 15 min after alfaxalone administration. The arterial pH decreased significantly during the first 30 min of the study, although no significant differences from basal values were observed in the arterial partial pressure of carbon dioxide (PaCO2). The results showed that alfaxalone in 2-hydroxypropyl-β-cyclodextrin a...Continue Reading
References
Sep 1, 1990·British Journal of Anaesthesia·W B RuncimanD G Selby
May 19, 1998·Anesthesia and Analgesia·D ZhengG L Ludbrook
Nov 24, 1999·British Journal of Anaesthesia·R N Upton, G L Ludbrook
Dec 5, 2003·The Veterinary Record·H Keates
Jun 29, 2005·The Veterinary Journal·A AndaluzF García
Jun 13, 2006·Veterinary Anaesthesia and Analgesia·Pierre J FerréHervé P Lefebvre
Sep 17, 2008·Veterinary Anaesthesia and Analgesia·William MuirTed Whittem
Sep 30, 2008·The Veterinary Record·N J GrintJ M Senior
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·T WhittemM G Ranasinghe
Jan 6, 2009·Veterinary Anaesthesia and Analgesia·William MuirTed Whittem
Jan 27, 2009·The Veterinary Record·M K MarshS K Maloney
Citations
Nov 28, 2013·TheScientificWorldJournal·Anna AndaluzXavier Moll
Jul 9, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Silvia Villaverde-MorcilloIgnacio A Gómez de Segura
Feb 17, 2015·Journal of the South African Veterinary Association·T Brighton DzikitiEva R Garcia
Jul 10, 2013·Placenta·E DomínguezL Fresno
May 31, 2013·Journal of the South African Veterinary Association·T Brighton Dzikiti
Oct 23, 2012·The Veterinary Journal·Xavier MollAnna Andaluz
Mar 29, 2014·Veterinary Anaesthesia and Analgesia·Patience S NdawanaLoveness N Dzikiti
May 2, 2014·BioMed Research International·Saul ChemongesJohn F Fraser
Nov 3, 2016·Journal of Veterinary Pharmacology and Therapeutics·K W ChiuT Whittem
Oct 18, 2014·The Veterinary Record·Daniel CostaAnna Andaluz
Dec 23, 2017·The Journal of Veterinary Medical Science·Sayed Fathi El-HawariKazuto Yamashita
Sep 14, 2018·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Maggie WilliamsÅsa Fahlman
Aug 27, 2019·American Journal of Veterinary Research·Morgan H OakleafJeremiah T Easley
Jun 1, 2019·Journal of the American Veterinary Medical Association·Julie A BalkoSathya K Chinnadurai
Sep 24, 2015·Veterinary Record Open·T B DzikitiL N Dzikiti
Jul 14, 2012·The Veterinary Record·M M GranadosR Gómez-Villamandos
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Mahmoud M AbouelfetouhYi Ding
May 24, 2021·Veterinary Anaesthesia and Analgesia·Molly PattersonKathreen Ruckstuhl
Mar 21, 2017·Veterinary Anaesthesia and Analgesia·Kate L WhiteJohn Harris
May 20, 2014·Veterinary Anaesthesia and Analgesia·Ana M del ÁlamoMark E Payton