The 'efferent' function of capsaicin-sensitive nerves: ruthenium red discriminates between different mechanisms of activation.

European Journal of Pharmacology
C A MaggiA Meli

Abstract

We have investigated the ability of Ruthenium Red, an inorganic dye with calcium entry blocking properties, to interfere with the 'efferent' function of capsaicin-sensitive sensory nerves. These nerves were activated in the guinea-pig isolated bronchus (atropine in the bath) or left atria (reserpine-pretreated animals, atropine in the bath) by electrical field stimulation or with capsaicin. Both stimuli produced a contraction of the bronchus and a positive inotropic response in the atria, responses which are mediated by endogenous neuropeptides (tachykinins in the bronchus, calcitonin gene-related peptide in the atria) released from sensory nerves. Ruthenium Red (10 microM for 20 min in both cases) selectively inhibited the responses produced by the administration of capsaicin, while leaving the responses to electrical field stimulation unaffected. Likewise, the bronchoconstrictor response to exogenous neurokinin A and the atrial positive inotropic response to calcitonin gene-related peptide were unaffected by Ruthenium Red. A prejunctional site of action of Ruthenium Red was confirmed in release experiments where the dye strongly inhibited the capsaicin-evoked outflow of calcitonin gene-related peptide, which is taken as a mar...Continue Reading

References

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Citations

Sep 21, 1990·European Journal of Pharmacology·R AmannF Lembeck
Sep 4, 1990·European Journal of Pharmacology·M TakakiS Nakayama
May 14, 1992·European Journal of Pharmacology·M G BelvisiP J Barnes
May 4, 1995·European Journal of Pharmacology·M MolimardC Advenier
Apr 1, 1991·Journal of the Autonomic Nervous System·C A Maggi
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Dec 13, 2001·European Journal of Pharmacology·H YamamotoK Watanabe
Aug 27, 1997·European Journal of Pharmacology·H InoueY Koshihara
Mar 10, 2001·Respiration Physiology·M J Carr, B J Undem
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Tsukasa SakuradaShinobu Sakurada
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Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Mar 1, 1993·British Journal of Pharmacology·P GeppettiJ A Nadel
Nov 1, 1993·British Journal of Pharmacology·Z Y Wang, R Håkanson

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