The efficacy and safety of a clonidine/bupivacaine combination in caudal blockade for pediatric hernia repair

Anesthesia and Analgesia
W KlimschaM Semsroth

Abstract

We evaluated the analgesic efficacy and hemodynamic and respiratory safety of clonidine when added to bupivacaine for caudal blocks in 58 children aged 38 +/- 2 mo (mean +/- SEM). Patients scheduled for ambulatory hernia repair were randomly given a caudal injection (0.75 mL/kg) of either saline placebo (P group), bupivacaine, 0.25% (B group), bupivacaine plus epinephrine 1:200,000 (BE group), bupivacaine plus clonidine 1 microgram/kg (BC1 group), or bupivacaine plus clonidine 2 micrograms/kg (BC2 group). Postoperative measurements included duration of analgesia, hemodynamics, and respiratory monitoring for 6 h. Thereafter, parents assessed their child's analgesic requirements at home every 3 h for 18 h. The duration of analgesia (median [range]) was significantly longer (P < 0.05) in the BC1 and BC2 groups (360 [270-360] min and 360 [355-360] min, respectively) compared with the P (77[45-190]), B (346[105-360]), or BE group (300[75-360]). Similarly, the BC1 and BC2 groups required less additional analgesic within the first 24 h. All groups showed a significant decrease in mean arterial pressure compared with baseline values, but the differences among the groups were not significant. Bradycardia and respiratory depression were ...Continue Reading

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Citations

Oct 5, 2010·Indian Journal of Anaesthesia·Sukhminder Jit Singh BajwaAparajita Panda
Dec 21, 2002·Best Practice & Research. Clinical Anaesthesiology·John B Eck, Allison Kinder Ross
May 24, 2016·Anesthesia, Essays and Researches·Vigya GoyalKrishnaprabha Radhakrishnan
Mar 15, 2002·Anesthesiology Clinics of North America·Mark W Farrar, Jerrold Lerman
Oct 4, 2006·Current Opinion in Anaesthesiology·R Aantaa, T Manner
Feb 1, 2007·Paediatric Anaesthesia·Nicole AlmenraderPaolo Pietropaoli
Sep 3, 2003·Paediatric Anaesthesia·Mark AnserminoCarolyne Montgomery
May 22, 2004·Paediatric Anaesthesia·Tom G Hansen, Steen W Henneberg
May 28, 2008·Paediatric Anaesthesia·Richard HowardUNKNOWN Association of Paediatric Anaesthetists of Great Britain and Ireland
Sep 24, 2004·Paediatric Anaesthesia·M PassarielloP Pietropaoli
May 22, 2004·Paediatric Anaesthesia·Wanda JoshiScott S Reuben
Mar 22, 2006·Acta Anaesthesiologica Scandinavica·T S YildizK Toker

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