The efficacy and safety of acenocoumarol and warfarin therapy in patients with lower limb deep vein thrombosis

Orvosi hetilap
Sándor Iván Bernát, László Rókusz

Abstract

Only few studies are available on the comparison of the efficacy and safety of the acenocoumarol and warfarin. The authors treated patients with deep vein thrombosis according to latest recommendations using D-dimer measurements and duplex ultrasound exams. To examine the efficacy and safety of the two anticoagulants in patients with lower limb deep vein thrombosis. The authors included 100 consecutive patients with lower limb dee deep vein thrombosis. The patients were treated with acenocoumarol or warfarin in doses to achieve INR values between 2 and 3.5 for six months. After 6 months the authors performed physical examination, D-dimer measurements and ultrasound exams, and determined the rate of unchanged thrombotic process, as well as the rate of complete and incomplete recanalisations. There was no significant difference in the number of INR determinations during treatment between the two groups (acenocoumarol group 442, warfarin group 416). The INR values were in the therapeutic range in 71.2% and 75.4% of patients in the acenocoumarol and warfarin groups, respectively. Dose adjustment was necessary in 129 and 84 times in the acenocoumarol and warfarin groups, respectively (p = 0.0025). The therapy was optimally effective...Continue Reading

References

Oct 27, 2006·The New England Journal of Medicine·Gualtiero PalaretiUNKNOWN PROLONG Investigators
Jul 2, 2008·Medicina clínica·Elvira Oliva BeriniAna María Pacheco Onrubia

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Citations

Mar 2, 2021·Journal of Clinical Pharmacy and Therapeutics·Maria Antonietta BarbieriEdoardo Spina

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