The efficacy and safety of autologous conditioned serum (ACS) injections compared with betamethasone and placebo injections in the treatment of chronic shoulder joint pain due to supraspinatus tendinopathy: a prospective, randomized, double-blind, controlled study

Medical Ultrasonography
Nemanja DamjanovGoran Tulic

Abstract

Autologous conditioned serum (ACS; marketed as Orthokine®) is an autologous blood product that has previously shown efficacy in treatment of joint osteoarthritis, spinal radiculopathy, tendon and muscle injuries in randomized controlled trials. In this 24-week, randomized, double-blind study, we compared the efficacy and safety of ACS with glucocorticoid (betamethasone) injections in chronic supraspinatus tendinopathy patients. Thirty-two patients with chronic supraspinatus tendinopathy were enrolled in the study. The ACS group received four ACS injections once weekly over four weeks and the glucocorticoid group received three betamethasone injections once weekly over three weeks with a placebo (saline) injection at week 4 into the enthesis and paratenon of the supraspinatus tendon. Study endpoints were pain intensity (VAS) and Constant Shoulder Score (CSS) assessed at weeks 0, 4 and 24. Shoulder pain intensity improved after 4 weeks and significantly improved after 24 weeks in patients treated with ACS compared with those treated with glucocorticoids (pain intensity week 4: ACS=22.0, glucocorticoid=32.0; week 24: ACS=15.0, glucocorticoid=40.0). CSS improved to a similar extent in both groups after 4 weeks. After 24 weeks, ACS ...Continue Reading

Citations

Apr 7, 2020·The Journal of Clinical Investigation·Thomas BuchheitRu-Rong Ji
Feb 28, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Christine TownsendAlfred C Gellhorn
Dec 31, 2020·Journal of Clinical Medicine·Edoardo Giovannetti de SanctisFrancesco Franceschi
Dec 29, 2020·Journal of Back and Musculoskeletal Rehabilitation·David M RobinsonJoanne Borg-Stein
Dec 11, 2021·Growth Factors·Seyed Kazem ShakouriReza Yarani

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