The efficacy and safety of dipeptidyl peptidase-4 inhibitors for type 2 diabetes: a Bayesian network meta-analysis of 58 randomized controlled trials

Acta Diabetologica
Juan LingKe-hu Yang

Abstract

The aim is to evaluate the efficacy and safety of dipeptidyl peptidase-4 inhibitors (DPP4-I: sitagliptin, saxagliptin, linagliptin, vildagliptin and alogliptin) in patients with type 2 diabetes. We searched the Cochrane Library, PubMed, EMBASE, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), and the Wanfang Database from inception to April, 2018. Randomized controlled trials were included if they compared the different versions of DPP4-I with each other or with placebo in treatment of type 2 diabetes. Bayesian network meta-analysis and pairwise meta-analysis were performed to evaluate the efficacy and safety of the different kinds of DPP4-I and placebo. The data were analyzed using STATA 12.0 and WinBUGS1.4 software. We identified 58 eligible studies (with 31356 patients) involving 14 treatment arms. Indirect comparison results showed that except for alogliptin, a decrease was found for all DPP4-I versus the placebo for hemoglobin A1c (HbA1c) with vildagliptin50 twice daily (BID) showing the highest probability. Linagliptin5 once daily (QD) decreased the level of fasting plasma glucose (FPG) the most for all DPP4-I versus the placebo; when comparing them with each other, alogliptin25QD was mor...Continue Reading

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Citations

Jun 9, 2020·Acta Diabetologica·Sebastiano Bruno SolertePaolo Fiorina
Jan 4, 2019·Acta Diabetologica·Giorgio SestiFrancesco Purrello
May 18, 2021·Frontiers in Endocrinology·Chin-Hsiao Tseng
Jun 5, 2021·Journal of the American Medical Directors Association·Katja S JustReinhard W Holl
Dec 24, 2021·The Journal of International Medical Research·Yucheng WuQingqing Zhang

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