The efficacy and safety of intramuscularly administered 15(S) 15 methyl prostaglandin E2 methyl ester for induction of artificial abortion.

American Journal of Obstetrics and Gynecology
W E BrennerL G Staurovsky

Abstract

The practicability of an intramuscular dose schedule of 10 mug of 15(S) 15 methyl prostaglandin E2 methyl ester [15(S) Me PGE2] administered every 4 hours was evaluated in 42 subjects from 7 to 20 menstrual weeks' gestation. Half of the subjects served as controls (Group I) and half of the subjects (Group II) were treated with a medication regimen of prochlorperazine, acetylsalicylic acid, diphenoxylate hydrochloride, and atropine sulfate to evaluate the regimen's effects. Although the 15(S) Me PGE2 dose schedule appeared to be effective (74 per cent aborted in 24 hours and 95 per cent aborted within 48 hours in a mean time of 18.9 hours), Group I (control) subjects frequently had side effects: 62 per cent had emesis, 86 per cent had diarrhea, 76 per cent had shivering, and 76 per cent had fever (greater than 100 degrees F.). Fewer Group II (medicated) subjects had side effects: 43 per cent had emesis, 19 per cent had diarrhea, 52 per cent had shivering, and 43 per cent had fever. The medication regimen did not appear to interfere with the abortifacient or oxytocic effects of the 15(S) Me PGE2 dose schedule, since Group I and Group II subjects had similar cumulative abortion rates, mean abortion times, and uterine activity. Alt...Continue Reading

References

Apr 1, 1975·American Journal of Obstetrics and Gynecology·G S BergerT D Kerenyi
Sep 10, 1974·Prostaglandins·T LeibmanG Randolph
Nov 1, 1974·American Journal of Obstetrics and Gynecology·T M KingW R Bell
Jan 1, 1972·Prostaglandins·N WiqvistM Toppozada
May 10, 1974·Prostaglandins·N WiqvistM Toppozada
Apr 30, 1971·Annals of the New York Academy of Sciences·S Karim
Mar 13, 1971·British Medical Journal·M P Embrey, K Hillier

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Citations

May 1, 1982·The American Journal of Medicine·C A Dinarello, S M Wolff
Dec 1, 1986·Cellular and Molecular Neurobiology·D B Briggs, D O Carpenter
Jan 1, 1989·Drug Metabolism Reviews·P L CarlA H Rezvani
Jun 1, 1984·Asia-Oceania Journal of Obstetrics and Gynaecology·G SakunthalaA Ramamurthy
Jan 1, 1984·Molecular Aspects of Medicine·J H Barnes

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