The Efficacy and Safety of Long-term Pirfenidone Therapy in Patients with Idiopathic Pulmonary Fibrosis

Internal Medicine
Kazumasa OgawaKazuma Kishi

Abstract

Objective Pirfenidone (PFD) is often used for years, but the efficacy and safety of long-term PFD therapy in patients with idiopathic pulmonary fibrosis (IPF) are not fully understood. Methods and Patients We retrospectively evaluated 46 patients with IPF who received PFD between February 2009 and August 2014. The efficacy and safety of PFD therapy were compared between 2 groups: long-term therapy patients who received PFD for over 1 year (group L, n=30, 65%) and short-term therapy patients who could not receive PFD for more than 1 year due to worsening of their condition or side effects (group S, n=16, 35%). Results The median age of the 46 patients was 70.5 years, and the median baseline % predicted forced vital capacity (%FVC) was 70.0%. The changes in the FVC in group L were -120 mL and -170 mL at 12 and 24 months after receiving PFD, respectively. The respective median survival times after PFD therapy in groups L and S were 1,612 days and 285 days (p<0.001). The patients in group L experienced a longer time free of acute exacerbation of IPF than those in group S (947 days vs. 145 days, p=0.001). A multivariate analysis revealed that %FVC <60% was a predictor of the inability to receive PFD for over 1 year (odds ratio 0.240...Continue Reading

References

Dec 10, 2009·The European Respiratory Journal·H TaniguchiUNKNOWN Pirfenidone Clinical Study Group in Japan
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
May 17, 2011·Lancet·Paul W NobleUNKNOWN CAPACITY Study Group
May 20, 2014·The New England Journal of Medicine·Talmadge E KingUNKNOWN ASCEND Study Group
May 20, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Dominique ValeyreRoland M du Bois
Sep 24, 2015·American Journal of Respiratory and Critical Care Medicine·Ulrich CostabelArata Azuma
Mar 5, 2016·Internal Medicine·Masashi BandoUNKNOWN Japan Pirfenidone Clinical Study Group
Jun 15, 2016·American Journal of Respiratory and Critical Care Medicine·Harold R CollardFernando J Martinez
Aug 28, 2017·Pulmonary Pharmacology & Therapeutics·Argyrios TzouvelekisDemosthenes Bouros
Sep 13, 2017·Respiration; International Review of Thoracic Diseases·Ulrich CostabelPaul W Noble

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Citations

Dec 27, 2018·The Laryngoscope·Emre Türkmen, Yavuz Selim Pata
Feb 19, 2020·Therapeutic Advances in Respiratory Disease·Lucia VietriElena Bargagli
May 7, 2019·European Journal of Hospital Pharmacy. Science and Practice·Borja Marcos RibesTeresa Aznar
Jul 24, 2021·The Korean Journal of Internal Medicine·Hyeontaek HwangJong Sun Park

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Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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