Abstract
QVAR [hydrofluoroalkane-134a beclometasone dipropionate (BDP)] produces equivalent asthma control to chlorofluorocarbon-based BDP inhalers, at approximately half the daily dose in adults, a probable consequence of the increased lung deposition of QVAR that results from its greater fine particle fraction. Recent studies have relied on the clinical experience with QVAR in adults as a basis for investigations in childhood asthma. Design considerations, such as the use of the breath-actuated Autohaler delivery device and measurement of direct health benefits, account for problems of variation in inspiratory flow, handling difficulties and low airways resistance that are associated with children. QVAR appears to be well tolerated in children with no clinically relevant adverse effects on adrenal function, bone metabolism or growth at recommended doses.
References
Jan 7, 1999·The European Respiratory Journal·C L LeachR J Boudreau
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·C Leach
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·W W BusseG L Colice
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·J A Vanden BurgtD Donnell
Jun 4, 2002·Pediatrics·Søren PedersenUNKNOWN Pediatric Study Group
Jul 11, 2002·European Journal of Clinical Pharmacology·Lester I HarrisonGail G Shapiro
Jul 12, 2002·The Journal of Allergy and Clinical Immunology·Stanley J SzeflerUNKNOWN Pediatric Study Group
Dec 12, 2002·Chest·Anjuli NayakMichael Welch
Feb 5, 2003·Pediatric Pulmonology·L AgertoftS Pedersen
Jun 12, 2003·The European Respiratory Journal·S G DevadasonP N Le Souëf
Jul 3, 2003·Paediatric Drugs·Tabitha L RandellPeter P van Asperen
Citations
Jul 3, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Charlotte M H H T RobroeksQuirijn Jöbsis
Oct 12, 2010·European Journal of Pediatrics·Wim M C van Aalderen, Aline B Sprikkelman
Aug 15, 2014·Advances in Therapy·Anna Bodzenta-Łukaszyk, Marek Kokot
Sep 18, 2012·British Journal of Clinical Pharmacology·Bo L K ChawesHans Bisgaard
Jun 3, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Willem M C van AalderenDavid Price
Jan 9, 2015·NPJ Primary Care Respiratory Medicine·Wim M van AalderenDavid Price
Apr 22, 2014·Pulmonary Pharmacology & Therapeutics·Mirco GovoniHans Bisgaard
Sep 1, 2016·Respiratory Medicine·Peter HaidlRolf Michael Cloes
Feb 20, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David I Bernstein, David B Allen
Sep 13, 2016·Expert Opinion on Drug Metabolism & Toxicology·Maria Gabriella MateraMario Cazzola
Mar 27, 2015·British Journal of Clinical Pharmacology·Piotr KunaIwona Stelmach
Apr 21, 2006·The Cochrane Database of Systematic Reviews·T J LassersonJ White
Dec 22, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Reham AljalamdehAlbert Bolhuis
Jan 9, 2010·The Journal of Allergy and Clinical Immunology·Chet LeachAllan Luskin