The efficacy and safety of tadalafil in United States and Puerto Rican men with erectile dysfunction

The Journal of Urology
A SeftelSanjeev Ahuja

Abstract

We evaluate the efficacy and safety of tadalafil, taken as needed, in men with mild to severe erectile dysfunction (ED) and assess sexual intercourse attempt patterns. In this multicenter, double-blind, placebo controlled, parallel study conducted in the United States and Puerto Rico 207 men with ED were randomized to placebo or 20 mg tadalafil for 12 weeks. The primary efficacy variables were changes from baseline in the mean International Index of Erectile Function erectile function domain score and mean per patient percentage of "yes" responses to Sexual Encounter Profile (SEP) diary questions 2 (successful penetration) and 3 (successful intercourse). The Global Assessment Question was a secondary end point and post hoc analyses on sexual intercourse attempt patterns were conducted. Men treated with tadalafil compared with placebo reported greater mean changes from baseline on the erectile function domain score (9.3 vs 0.3 with placebo, p <0.001) and on the mean per patient percentage of successful penetration (SEP question 2, 31.6% vs 2.3% with placebo, p <0.001) and successful intercourse attempts (SEP question 3, 43.6% vs 3.5% with placebo, p <0.001). The per treatment group percentage of successful intercourse attempts d...Continue Reading

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Citations

Feb 15, 2005·Urology·Culley CarsonUNKNOWN Trial Evaluating the Activity of Tadalafil for Erectile Dysfunction-United States (TREATED-US) Study Group
Dec 1, 2007·Clinical Interventions in Aging·Giovanni Vanni FrajeseGaetano Frajese
Jan 23, 2010·The Journal of Sexual Medicine·Ian EardleySung Won Lee
Oct 21, 2005·International Journal of Andrology·E CarosaE A Jannini
Jul 13, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Ying Lu GuoMelanie Chan
Jul 23, 2013·International Journal of Clinical Practice·W B SmithW J Hellstrom
Jul 30, 2005·Urology·Stephen H KingHunter Wessells
Feb 16, 2005·Expert Opinion on Pharmacotherapy·Sheila A Doggrell
Mar 12, 2016·Journal of Alzheimer's Disease : JAD·Andrew F TeichOttavio Arancio
Dec 22, 2006·International Journal of Impotence Research·S Doggrell
Jul 27, 2005·BJU International·Culley C Carson, Tom F Lue
Jul 1, 2013·Journal of Clinical Urology·Jas Kalsi, Asif Muneer
Dec 5, 2020·Expert Opinion on Pharmacotherapy·Ahmed M BakrAhmed I El-Sakka

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