The efficacy of 308-nm excimer laser/light (EL) and topical agent combination therapy versus EL monotherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials (RCTs)

Journal of the American Academy of Dermatology
Jung Min BaeGyong Moon Kim

Abstract

Combination therapies of excimer laser/light (EL) and various topical agents are widely used in the treatment of vitiligo. We sought to compare the efficacy of EL and topical agent combination therapy versus EL monotherapy for vitiligo. Manual searches of reference lists and computerized searches of the MEDLINE, EMBASE, and Cochrane library (from inception through December 15, 2014) were conducted to identify randomized controlled trials that assessed the efficacy of EL alone or in combination with topical agents for vitiligo. The primary outcome was treatment success (≥75% repigmentation), and the secondary outcome was treatment failure (<25% repigmentation); meta-analyses were performed when possible. We analyzed 8 randomized controlled trials comprising a total of 425 patches/patients. The combination of EL and topical calcineurin inhibitors (4 studies: relative risk 1.93, 95% confidence interval 1.28-2.91; number needed to treat 4.5, 95% confidence interval 2.9-10) was superior to EL monotherapy for vitiligo. There was insufficient evidence to support beneficial effects of topical vitamin-D3 analogs (3 studies) and corticosteroids (1 study). These findings are based on small numbers of randomized controlled trials and heter...Continue Reading

References

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Citations

Apr 10, 2017·The British Journal of Dermatology·J M BaeG S Choi
Sep 25, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Yih-An KingYu-Chen Huang
Dec 1, 2018·The Journal of Dermatological Treatment·Sanne E UitentuisAlbert Wolkerstorfer
Jan 18, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Léa DoussetJulien Seneschal
Jul 2, 2019·The British Journal of Dermatology·N Silpa-ArchaC Wongpraparut
Feb 19, 2020·Expert Opinion on Drug Safety·Torello LottiMohamad Goldust
Sep 4, 2019·Journal of Cutaneous Medicine and Surgery·Lyn GuentherYves Poulin
Jan 3, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K Fritz, C Salavastru
Oct 10, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Yih-An KingYu-Chen Huang
Aug 14, 2020·Archives of Dermatological Research·Yujie DongXiaojie Sun
Sep 11, 2020·Photodermatology, Photoimmunology & Photomedicine·Jung Min BaeChul Jong Park
Jan 7, 2021·The Journal of Dermatology·Christina Bergqvist, Khaled Ezzedine
Jun 8, 2021·Experimental and Therapeutic Medicine·David Emmanuel Kubelis-LópezJorge Ocampo-Candiani
Mar 11, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Christina Bergqvist, Khaled Ezzedine

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