The efficacy of a hydroxyapatite composite as a biodegradable antibiotic delivery system

Clinical Orthopaedics and Related Research
B BuranapanitkitChitchamai Ovatlarnporn

Abstract

Local biodegradable carriers have been studied for use as a skeletal drug delivery system. This study investigated the efficacy of a local biodegradable composite composed of hydroxyapatite, plaster of Paris, and chitosan impregnated with antibiotics to treat methicillin-resistant Staphylococcus aureus. The composite, impregnated with vancomycin, fosfomycin, or sodium fusidate was tested for its sustained elution characteristics during 3 months and compared with similarly impregnated polymethylmethacrylate using the modified disc diffusion technique. Physicochemical properties using scanning electron microscopy and xray diffraction analysis of each preparation also were analyzed. Vancomycin and fosfomycin incorporated into the hydroxyapatite composite inhibited the organism for 3 months, whereas sodium fusidate was effective only for 3 weeks. Vancomycin and fosfomycin loaded into the hydroxyapatite composite had a significantly better inhibitive effect than when loaded in polymethylmethacrylate, whereas sodium fusidate loaded in polymethylmethacrylate showed a significantly better inhibitive effect than when loaded in the hydroxyapatite composite. Scanning electron microscopy and xray diffraction analysis elucidated the pattern...Continue Reading

References

May 1, 1977·The Journal of Bone and Joint Surgery. British Volume·J HillR Blowers
Jul 1, 1992·The Journal of Bone and Joint Surgery. British Volume·Y ShintoK Ono
Mar 1, 1991·The Journal of Bone and Joint Surgery. British Volume·G WeiY Ikada
Feb 1, 1990·The Journal of Antimicrobial Chemotherapy·R R Coombs
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·R MuzzarelliP E Varaldo
Aug 14, 1980·The New England Journal of Medicine·F A Waldvogel, P S Papageorgiou
Jan 1, 1982·The Journal of Bone and Joint Surgery. British Volume·R Bayston, R D Milner
Sep 1, 1982·Annals of Internal Medicine·C Watanakunakorn
Dec 1, 1994·Biomaterials·G PelusoG Balsamo
Sep 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T MiclauR W Lindsey
Aug 1, 1996·Clinical Orthopaedics and Related Research·R W KendallJ H Ngui-Yen
Jan 1, 1996·Journal of Biomedical Materials Research·C HamanishiT Kitahashi
Sep 18, 1997·Journal of Medical Microbiology·M ItokazuK Watanabe
Jul 31, 1998·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·T OzakiH Inoue
Apr 2, 1999·Clinical Orthopaedics and Related Research·J T MaderJ Calhoun
Sep 3, 1999·The Orthopedic Clinics of North America·B K TayD S Bradford
Mar 30, 2000·Clinical Orthopaedics and Related Research·H D MoehringS A Olson
Jul 6, 2000·Drugs·K Kanellakopoulou, E J Giamarellos-Bourboulis
Nov 4, 2000·International Journal of Pharmaceutics·A K Jain, R Panchagnula
Jan 12, 2001·Clinical Orthopaedics and Related Research·C M KellyP T Kim
Jun 26, 2001·The Journal of the American Academy of Orthopaedic Surgeons·N A EbraheimR Xu
Aug 2, 2002·Clinical Orthopaedics and Related Research·Mark E ShirtliffJon T Mader
Mar 1, 1959·American Journal of Surgery·L F PELTIER

❮ Previous
Next ❯

Citations

Aug 2, 2005·Clinical Orthopaedics and Related Research·Boonsin BuranapanitkitNatnicha Ingviya
Apr 19, 2008·Clinical Orthopaedics and Related Research·Scott P NoelWarren O Haggard
May 29, 2009·Orthopedics·Melvin D HelgesonScott B Shawen
Nov 17, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M PopovicC Joukhadar
Jun 11, 2016·Experimental and Therapeutic Medicine·Xiaoming LiuBaoxing Li
Jan 4, 2007·Journal of Orthopaedic Surgery·A KrisanapiboonK Oungbho
Apr 13, 2007·Journal of Orthopaedic Surgery·J VechasilpS Yuenyongsawad
Aug 19, 2015·Surgical Infections·Vasileios I SakellariouPanayiotis J Papagelopoulos
Jun 9, 2006·Clinical Orthopaedics and Related Research·Metin Manouchehr EskandariCengiz Yilmaz
Jul 17, 2008·Biomechanics and Modeling in Mechanobiology·Fabio GalbuseraGabriele Dubini
Nov 26, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mark V Thomas, David A Puleo
Jan 15, 2014·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·K E RothP M Rommens
Aug 14, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Anna BelcarzJustyna Niedźwiadek
Aug 2, 2005·Clinical Orthopaedics and Related Research·Arlen D Hanssen
Feb 14, 2007·Journal of Biomedical Materials Research. Part a·G M SalzmannJ Schauwecker
Jul 30, 2008·Pharmaceutical Research·Tatsuo TakahashiKen-ichi Miyamoto
Jan 14, 2016·Journal of Materials Science. Materials in Medicine·Dario PuppiFederica Chiellini
Feb 2, 2011·The Journal of Bone and Joint Surgery. British Volume·M El-HusseinyF S Haddad
Nov 22, 2005·The Veterinary Clinics of North America. Equine Practice·Alison J Morton
Jan 2, 2008·Revue de chirurgie orthopédique et réparatrice de l'appareil moteur·T BauerA Lortat-Jacob

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.