The efficacy of a multimodal analgesia protocol in preventing heterotopic ossification after acetabular fractures surgery

International Journal of Clinical Pharmacy
Liang ChengYong Zhu

Abstract

Background Heterotopic ossification (HO) after joint surgery is always a disturbing problem for patients and surgeons. Prophylaxis is the most effective therapy. Objective To assess the efficacy and safety of a multimodal analgesia protocol that included parecoxib and celecoxib in preventing HO after acetabular fracture surgery. Setting Selecting patients from trauma registry of our hospital. Method We identified 259 patients who had acetabular fracture surgery between January 2008 and December 2014. Hundredsixty-three patients received parecoxib and celecoxib (Group A) and 96 patients received no prophylaxis (Group B). The presence of HO was assessed according to the classification of Brooker et al. at the 12 month postoperative visit. Main outcome measure The differences in HO incidence and severity between the two groups. Results 49 patients (30.0%) developed HO in the Group A and 44(45.8%) in Group B. The difference in total HO incidence between the two groups was significant (P = 0.011 < 0.05, χ2 = 6.530, OR 0.508, 95% CI (0.301-0.857). Severe HO (Brooker grade III or IV) developed in 15 patients (9.2%) in Group A and 17 patients (17.7%) in Group B. Brooker grade I + II was 34(20.9%) and 27(28.1%) in each group. The differ...Continue Reading

References

Dec 13, 2006·The Journal of Bone and Joint Surgery. British Volume·M A KarunakarJ F Kellam
Sep 30, 2008·Clinical Orthopaedics and Related Research·Taco J Blokhuis, Jan Paul M Frölke
Jul 17, 2009·Current Opinion in Anaesthesiology·Asokumar Buvanendran, Jeffrey S Kroin
Mar 13, 2012·Expert Opinion on Pharmacotherapy·George PavlouEleftherios Tsiridis
Sep 27, 2012·Journal of Orthopaedic Trauma·Aaron NauthEmil H Schemitsch

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Citations

Dec 3, 2021·Archives of Orthopaedic and Trauma Surgery·Ramakanth R YakkantiStephen M Quinnan

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