The efficacy of a topical gel prepared using Lake Urmia mud in patients with knee osteoarthritis

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Nemati MahboobValizadeh Hadi

Abstract

Osteoarthritis (OA) is characterized by progressive cartilage degradation and secondary inflammation of the synovial membrane. Studies have shown that mud therapy may influence serum levels of several cytokines involved in the pathogenesis of OA and chondrocyte metabolism. The main targets of our research were to make use of Lake Urmia mud for topical gel formulation, evaluation of the possible therapeutic effects of this gel on symptoms of patients with knee OA and the evaluation of serum tumor necrosis factor-alpha (TNF-alpha) level after mud therapy in comparison with the application of a placebo. Fifty (50) patients suffering from knee OA participated in this study and randomized into two groups: case group and control group. Patients in the case group received mud therapy and the placebo was applied to patients in the control group. Three (3) parameters including pain, morning stiffness, and joint functionality were assessed in all patients. Visual analogue scale and Western Ontario McMaster Osteoarthritis index (WOMAC) were the employed scales for pain assessment. Functional capacity was evaluated by using WOMAC functional capacity and WOMAC global index. All the mentioned steps were done before and after treatment. Blood...Continue Reading

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Citations

Apr 11, 2013·Zeitschrift für Rheumatologie·A-M BeerU Lange
Mar 22, 2016·Annals of Physical and Rehabilitation Medicine·Romain ForestierAlain Francon
Feb 18, 2011·Osteoarthritis and Cartilage·G A HawkerI Stanaitis
May 20, 2016·American Journal of Physical Medicine & Rehabilitation·Sinan KardeşMüfit Zeki Karagülle
Aug 30, 2018·Postgraduate Medicine·E C Rodriguez-Merchan
May 18, 2019·Dermatologic Therapy·Somayyeh KhalilzadehMalihe Tabarrai
Jul 19, 2018·Journal of Complementary & Integrative Medicine·Reshma JogdandN K Manjunath
Sep 26, 2015·Journal of Back and Musculoskeletal Rehabilitation·Gonca Odemis GungenSimin Rota
Jun 9, 2018·International Journal of Molecular Sciences·Isabel GálvezEduardo Ortega-Rincón
Jul 24, 2015·American Journal of Physical Medicine & Rehabilitation·Jie XiangJian'an Li
Jan 11, 2019·Zeitschrift für Rheumatologie·G DischereitU Lange
Apr 21, 2018·International Journal of Biometeorology·Jose Manuel Carbajo, Francisco Maraver
Mar 20, 2021·International Journal of Biometeorology·Daniela D'AngeloPrimiano Iannone

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Methods Mentioned

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