The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R JoverGastrointestinal Oncology Group of the Spanish Gastroenterological Association

Abstract

The aim of this study is to evaluate if mismatch repair (MMR) defective colorectal cancer has a different response to adjuvant 5-fluorouracil (5-FU) chemotherapy in a cohort of patients prospectively followed during 5 years. The cohort included 754 surgically treated patients with colorectal cancer. MMR status was diagnosed by MLH1 and MSH2 immunohistochemistry and microsatellite instability analysis. Median follow-up was 49.2 months (range 1-73). At inclusion, 505 patients were diagnosed as TNM II or III stage, analysis of the efficacy of adjuvant chemotherapy was made on this population. Adjuvant chemotherapy was applied to 248 patients (98.2% 5-FU based). MMR deficiency was found in 76 patients (10.1%). No differences were found in overall survival (log-rank p=0.3) or disease-free survival (log-rank p=0.3) regarding MMR status. Adjuvant chemotherapy improves survival in patients in the II or III stage, but this improvement is only evident in patients with MMR-competent tumours (log-rank p=0.00001). Survival of patients with MMR-defective tumours does not improve with adjuvant chemotherapy (log-rank p=0.7). A multivariate analysis showed an independent effect of the interaction between MMR status and adjuvant chemotherapy (Ha...Continue Reading

References

May 7, 1993·Science·S N ThibodeauD Schaid
Jun 26, 1999·Gastroenterology·J M CarethersC R Boland
Jun 22, 2000·Gut·J M WheelerN J Mortensen
Apr 20, 2001·The New England Journal of Medicine·T WatanabeS R Hamilton
Nov 9, 2002·Lancet·P L BarrattUNKNOWN UKCCCR AXIS trial collaborators. Adjuvant X-ray and Fluorouracil Infusion Study
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Christian N ArnoldC Richard Boland
Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
Apr 28, 2005·JAMA : the Journal of the American Medical Association·Virgínia PiñolUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
May 6, 2005·The New England Journal of Medicine·Heather HampelAlbert de la Chapelle
Nov 22, 2005·Gut·R JoverUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Piero BenattiGiovanni Lanza
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Barbara JungJohn M Carethers
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni LanzaLuigi Cavazzini
Feb 8, 2007·Journal of the National Cancer Institute·Rosa M XicolaUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association

❮ Previous
Next ❯

Citations

May 26, 2006·International Journal of Colorectal Disease·C LambertiT Sauerbruch
Dec 17, 2009·Familial Cancer·Wilfredo E De Jesus-MongeMarcia Cruz-Correa
May 28, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cristina FerrásNiels de Wind
Mar 2, 2010·Nature Reviews. Clinical Oncology·Frank A Sinicrope
Feb 24, 2010·Nature Reviews. Clinical Oncology·Madeleine HewishAlan Ashworth
Nov 3, 2010·Clinics in Colon and Rectal Surgery·Robert Gryfe
May 21, 2011·Journal of the National Cancer Institute·Frank A SinicropeDaniel J Sargent
Feb 2, 2012·Mutagenesis·Sergi Castellví-BelUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
May 16, 2009·Current Opinion in Oncology·Frank A Sinicrope, Daniel J Sargent
Nov 26, 2010·The American Journal of Surgical Pathology·Angela HydeBanfield Younghusband
Nov 29, 2012·The Cancer Journal·Zhi Ven Fong, Jordan M Winter
May 28, 2011·Journal of Gastroenterology and Hepatology·Yong Sik YoonJin Cheon Kim
Jan 29, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K Newton, J Hill
Nov 3, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K F NewtonJ Hill
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L AnningO Will
Feb 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frank A Sinicrope, Daniel J Sargent
Feb 1, 2012·Onkologie·Dirk Arnold, Alexander Stein
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert de la Chapelle, Heather Hampel
Apr 25, 2012·Annals of Surgical Oncology·Ryota NakanishiYoshihiko Maehara
Nov 17, 2011·Drugs·Alexander SteinHans-Joachim Schmoll
Mar 23, 2011·Future Oncology·Frank A Sinicrope, Zhineng Jayson Yang
Jun 1, 2011·Radiology and Oncology·Matej Horvat, Borut Stabuc
Apr 26, 2014·World Journal of Gastroenterology : WJG·Jung Ho Kim, Gyeong Hoon Kang
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Xavier Sagaert
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tim ArlowAlison Gammie
Mar 7, 2014·Experimental and Molecular Pathology·Mariana Petaccia de MacedoIsabela Werneck da Cunha
Jul 16, 2010·Clinical & Developmental Immunology·Kristen M DrescherHenry T Lynch
Apr 14, 2012·Drug Metabolism Reviews·Jose J G MarinOscar Briz
Feb 6, 2016·Gastroenterología y hepatología·María Carmen Areses ManriqueJoaquín Cubiella
Dec 18, 2013·Seminars in Diagnostic Pathology·Andrew M Bellizzi
Jun 4, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Miew Keen Choong, Guy Tsafnat
Dec 17, 2010·Critical Reviews in Oncology/hematology·Dianne M HeijinkJan H Kleibeuker
Jul 16, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cecilia GuastadisegniEugenia Dogliotti
Nov 2, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D KlingbielS Tejpar
Sep 25, 2009·British Journal of Pharmacology·Long Shan LiDavid A Boothman
Jun 26, 2012·Journal of Surgical Oncology·Jordan M WinterJonathan R Brody

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gut
R JoverGastrointestinal Oncology Group of the Spanish Gastroenterological Association
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Gaëtan Des GuetzBernard Uzzan
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Daniel J SargentSteven Gallinger
© 2022 Meta ULC. All rights reserved