Abstract
Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p = 0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy.
References
Jan 12, 2000·Free Radical Research·P C HollmanM B Katan
May 3, 2000·Journal of Physiology, Paris·F PakodiG Mózsik
Jun 13, 2002·Critical Reviews in Food Science and Nutrition·Ora BurgerItzhak Ofek
Nov 17, 2004·Molecular and Cellular Biochemistry·Archana ChatterjeeSidney J Stohs
Dec 8, 2004·Diagnostic Microbiology and Infectious Disease·Haim ShmuelyItzhak Ofek
Apr 7, 2005·Helicobacter·Lian ZhangWei-cheng You
Nov 24, 2005·Helicobacter·Rocco Maurizio ZagariFranco Bazzoli
Nov 30, 2006·Molecular and Cellular Biology·Brenden RickardsGary LeRoy
May 10, 2007·Molecular Nutrition & Food Research·Haim ShmuelyItzhak Ofek
Mar 7, 2008·Helicobacter·Ruihua ShiGuoxin Zhang
Dec 3, 2008·Applied and Environmental Microbiology·Joseph C BrownXiuping Jiang
Jun 12, 2009·The Journal of Nutrition·Jason DeFuriaMartin S Obin
Jun 30, 2009·Cytokine·Matilde R ChacónJoan Vendrell
Apr 8, 2010·Journal of Gastroenterology and Hepatology·Kwong Ming Fock, Tiing Leong Ang
May 21, 2010·Cancer Prevention Research·Gerd BobeAmanda J Cross
May 12, 2012·The Lancet Oncology·Catherine de MartelMartyn Plummer
Jan 9, 2013·Journal of Applied Microbiology·J C Brown, X Jiang
Mar 5, 2013·Journal of Physiology and Biochemistry·Amr M Abbas, Hussein F Sakr
May 28, 2013·Gut and Liver·Tae Ho KimJin Il Kim
May 24, 2014·Phytotherapy Research : PTR·Edgar PasteneApolinaria García
May 29, 2014·Gastroenterology Research and Practice·Dae Young CheungJae Kwang Kim
Feb 3, 2015·Gastroenterology Research and Practice·Su Jin Hong, Sang Woo Kim
Sep 16, 2015·Helicobacter·Anthony O'ConnorSpiros Ladas
Citations
Jan 9, 2019·Frontiers in Physiology·David PorrasSonia Sánchez-Campos
Oct 1, 2020·Foods·Jose Manuel SilvanAdolfo J Martinez-Rodriguez
Jul 3, 2021·Antioxidants·Jose Manuel SilvanAdolfo J Martinez-Rodriguez
Sep 28, 2021·Critical Reviews in Microbiology·Cláudia SousaLuís D R Melo