The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: a systematic review and meta-analysis

Complementary Therapies in Medicine
Linda L D ZhongYao Tong

Abstract

Although Chinese herbal medicine (CHM) has been widely used as an adjunctive therapy for colorectal cancer in Asia, its efficacy is not well defined. The purpose of this systematic review is to assess the efficacy of CHM as an adjunctive therapy to chemotherapy for the patients with colorectal cancer. Randomized controlled trials with CHM to treat colorectal cancer were extensively searched in seven databases. Two researchers independently assessed the quality and validity of included trials and extracted outcome data for synthesis. 20 trials were included for analysis. Compared to using chemotherapy alone, CHM combined with chemotherapy significantly increased 1- and 3-year survival rate [odds ratio (OR) 2.41, 95% confidence interval (CI) 1.32-4.41; OR 2.40, 95% CI 1.49-3.87]. The combined therapy significantly slowed colorectal cancer progression (OR 0.50, 95% CI 0.32-0.77) and improved quality of life (OR 3.43, 95% CI 2.35-5.02). It had positive effects in immunoregulation. CHM as an adjunctive therapy also had significant advantages in reducing the adverse effects of chemotherapy. This systematic review suggests that CHM as an adjunctive therapy with chemotherapy versus chemotherapy alone has significant efficacy in terms o...Continue Reading

References

Jan 1, 1990·International Journal of Immunopharmacology·T KawakitaK Nomoto
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1981·Cancer·A B MillerA Winkler
Jan 1, 1994·The American Journal of Chinese Medicine·Y HorieK Hamano
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Sep 29, 2000·BMJ : British Medical Journal·P Boyle, J S Langman
Nov 4, 2000·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·A SparberS M Steinberg
Nov 18, 2000·BMJ : British Medical Journal·A Young, D Rea
Feb 2, 2002·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·F KronenbergD Eskinazi
Mar 24, 2004·Integrative Cancer Therapies·Keith I Block, Mark N Mead
Jun 11, 2004·Advance Data·Patricia M BarnesRichard L Nahin
Feb 9, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A MolassiotisE Patiraki
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D M ChaseM L Berman
Nov 23, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C HassanS Morini
Jan 16, 2007·Cancer Letters·William C S Cho, Kwok N Leung
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 6, 2007·Journal of Ethnopharmacology·William Chi Shing Cho, Kwok Nam Leung
Mar 20, 2008·World Journal of Gastroenterology : WJG·Gerardo Rosati, Domenico Bilancia
Jul 9, 2008·World Journal of Gastroenterology : WJG·Jochem van der Voort van ZijpMarc D Basson
Apr 14, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Wen-Hua MaRui-Ming Zhang
Jun 16, 2010·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Guolin WuFulin Xiong
Dec 15, 2010·International Journal of Oncology·Bai-Cheng HeBing-Qiang Zhang
May 14, 2011·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Jin-Chang HuangHui Wang
Mar 2, 2012·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Sixia HuangJinhui Tian
Apr 26, 2014·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Xiao ChenPing Zhou
May 3, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Jie HanJiaoying H Wang
Oct 3, 2015·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Lixiang ZhengYue Wang
Feb 6, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Andrew T WongDavid Schreiber

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Citations

May 6, 2014·Current Treatment Options in Oncology·Maciej SałagaJakub Fichna
Dec 19, 2013·BMC Complementary and Alternative Medicine·Hai-Yong ChenZhang-Jin Zhang
Jan 15, 2015·International Journal of Molecular Sciences·Amr AminRegine Schneider-Stock
Dec 18, 2013·Phytotherapy Research : PTR·Menghua ChenAnthony L Zhang
May 18, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Xu SunJin-Ping Li
Dec 17, 2014·BMC Complementary and Alternative Medicine·Tsai-Feng LiShu-Ling Fu
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Chia-Woei WangChen-Jei Tai
May 31, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Libing ZhuQi Wang
Dec 27, 2019·Integrative Cancer Therapies·Seong Min LeeMin Kyung Hyun
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiuchen QiZhongxi Zhao
Aug 16, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yifei DaiWeijie Qiang

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