The efficacy of dexamethasone reducing postoperative pain and emesis after total knee arthroplasty: A systematic review and meta-analysis

International Journal of Surgery
Zheng-Rui FanXin-Long Ma

Abstract

Total knee arthroplasty (TKA) is gradually emerging as the treatment of choice for end-stage osteoarthritis. In the past, Perioperative dexamethasone treatment is still a controversial subject in total knee arthroplasty. Therefore, we write this systematic review and meta-analysis to evaluate the efficacy of dexamethasone on pain and recovery after Total knee Arthroplasty. Embase, Pubmed, and Cochrane Library were comprehensively searched. Randomized controlled trials, cohort studies were included in our meta-analysis. Eight studies that compared dexamethasone groups with placebo groups were included in our meta-analysis. The research was reported according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Randomized controlled trials were included in our meta-analysis. Our study demonstrated that the dexamethasone group was more effective than the placebo group in term of VAS score at 24 h(P < 0.00001), 48 h(P = 0.0002); Opioid consumption (P < 0.00001); postoperative nausea (P < 0.00001); and Inflammatory factors of CPR at 24 h (P = 0.003). Our meta-analysis demonstrated that dexamethasone decreased postoperative pain, the incidence of POVN, and total opioid consumption effectively...Continue Reading

Associated Clinical Trials

Citations

May 21, 2019·Expert Opinion on Drug Safety·M L van ZuylenM W Hollmann
Sep 9, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Davide PrevitaliChristian Candrian
Mar 4, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Lukas EckhardWolfgang Fitz
Oct 27, 2020·European Journal of Anaesthesiology·Timmy Chi Wing ChanKwong Yuen Chiu
Mar 10, 2021·The Journal of International Medical Research·Youguang ZhuoYiyuan Zhang
Dec 18, 2020·Orthopaedics & Traumatology, Surgery & Research : OTSR·Xingwang ChengXia Zhang
Jul 8, 2021·The Journal of Bone and Joint Surgery. American Volume·Joseph A KaramJavad Parvizi

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