The efficacy of donepezil hydrochloride on memory functioning in three adolescents with severe traumatic brain injury

Brain Injury : [BI]
Melissa TrovatoJames Christensen

Abstract

To explore efficacy of donepezil on memory in adolescents with severe traumatic brain injury (TBI). Single subject, unblinded, multiple baseline design. Memory functioning was examined in three adolescents with TBI on and off medication (5 and 10 mg) using the Selective Reminding Test. Four variables were examined: Total recall (TR) = number of words total words recalled, Long Term Storage (LTS) = words recalled on two trials in a row, Consistency of Long Term Retrieval (CLTR) = words continuously recalled, Delay = number of words recalled after delay. On medication, three out of three participants demonstrated better memory. Two showed greatest improvement on 10 mg. All participants demonstrated improvement in TR and LTS. Two participants demonstrated improved CLTR. No participants displayed improvement in Delay. No adverse side effects were reported. Results suggests that donepezil may be effective in improving memory in adolescents with severe TBI and warrant further examination.

References

Jan 1, 1990·Journal of Clinical and Experimental Neuropsychology·H S Levin
Jan 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·A H van Zomeren, W van den Burg
Jun 1, 1985·Journal of Clinical and Experimental Neuropsychology·H J Hannay, H S Levin
Jan 1, 1995·Journal of the International Neuropsychological Society : JINS·K O YeatesD C Delis
Jul 7, 2001·Archives of Physical Medicine and Rehabilitation·C A MasanicM Simard
Nov 12, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·James A BourgeoisSean Minjares
Mar 1, 2003·Epilepsy & Behavior : E&B·R S FisherH Burke
Aug 21, 2003·The Journal of Neuropsychiatry and Clinical Neurosciences·Neil S KayeRichard Ivins

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Citations

Aug 6, 2013·Brain Injury : [BI]·Christos K NikopoulosKostas Konstantopoulos
Jun 24, 2008·Brain Injury : [BI]·Norman A Poole, Niruj Agrawal
Jan 24, 2016·Brain Research·Saurabha BhatnagarRoss Zafonte
Oct 25, 2016·Experimental Neurology·Blessen C EapenDavid X Cifu
Jun 4, 2008·The Journal of Head Trauma Rehabilitation·Javier BallesterosJosé I Quemada
Feb 23, 2020·Critical Care Nursing Quarterly·Jessica TraegerJason Makii
Nov 16, 2013·The Spanish Journal of Psychology·Vanessa B R LemeZilda A P Del Prette
Jan 12, 2017·Behavioural Neurology·Rahul SinghBrandon P Lucke-Wold

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.