PMID: 9432409Mar 1, 1996Paper

The efficacy of doxycycline as a pleural sclerosing agent in malignant pleural effusion: a prospective study

Respirology : Official Journal of the Asian Pacific Society of Respirology
C PulsiripunyaS Charoenratanakul

Abstract

To determine the efficacy of doxycycline in producing pleuroedesis in patients with malignant pleural effusion (MPE), 31 documented cases of MPE, aged 19-82 years were prospectively studied. Pleural sclerosis was done with 500 mg of doxycycline. Response regarding respiratory symptoms and pleural fluid accumulation were evaluated monthly. At one month, 27 patients were evaluable (4 dropped out). All responded and required no therapeutic thoracentesis. At 3 months, 13 patients dropped out, only 14 patients were evaluable. It revealed that 13 out of 14 patients (92%) responded. Only one patient failed and required therapeutic thoracentesis. Five and two patients came for assessment at 6 and 12 months, respectively. They still benefited from doxycycline pleurodesis. Side effects including low grade fever in 30% of patients, moderate to severe pain in 60% and troublesome cough with hemoptysis in one patient (3%) were noted. Doxycycline is an effective agent in controlling MPE. It was successful in every patient at 1 month and in 92% at 3 months. At 6 and 12 months quite a few patients survived for evaluation. However, they still benefited from doxycycline pleurodesis. Side effects were tolerable.

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Citations

Dec 28, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·P CharoenpanW Suwansathit
Jun 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alain TremblayMargaret M Kelly
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Katrina L MealeyDeborah T Kochevar
Nov 8, 2005·Postgraduate Medical Journal·A R MedfordN Maskell
Jul 20, 2012·International Journal of Nanomedicine·Natasha F CoverArun Kumar
May 3, 2003·Thorax·G AntunesUNKNOWN Pleural Diseases Group, Standards of Care Committee, British Thoracic Society
Oct 6, 2007·Chest·Paul A KvaleUNKNOWN American College of Chest Physicians
Apr 13, 2010·The Medical Clinics of North America·Fraser J H BrimsY C Gary Lee
Feb 24, 2001·Journal of Vascular and Interventional Radiology : JVIR·M V CaliendoD L Waldman
Oct 1, 2011·Journal of Surgical Oncology·Jussuf T KaifiMichael F Reed
Aug 9, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Siyamek Neragi-Miandoab
Mar 22, 2008·Respiratory Medicine·Ghulam Khaleeq, Ali I Musani
Feb 27, 2018·Expert Review of Respiratory Medicine·Rachel M MercerNajib M Rahman
May 11, 2005·Experimental Brain Research·Hanifa Dostmohamed, Vincent Hayward
Dec 2, 2005·Archives of Microbiology·Allison M L van de MeeneRobert W Roberson
Jan 16, 2003·Chest·Paul A KvaleUNKNOWN American College of Chest Physicians

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