Jul 25, 2013

The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease

International Journal of Molecular Sciences
Kiyoshi KikuchiEiichiro Tanaka

Abstract

Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardial infarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosis. This review evaluates the potential of edaravone for treatment of cardiovascular disease, and covers clinical and experimental studies conducted between 1984 and 2013. We propose that edaravone, which scavenges free radicals, ...Continue Reading

  • References141
  • Citations32

Citations

Mentioned in this Paper

Ischemic Cerebrovascular Accident
Ischemia
Pathogenic Aspects
Necrosis
Pathogenesis
Phenylmethylpyrazolone
Blood Vessel
Brain
Free Radicals
MCI 186

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