The efficacy of exit site povidone-iodine ointment in the prevention of early peritoneal dialysis-related infections

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
N M WaiteI W Fong

Abstract

Infections are the main complications of peritoneal dialysis, and currently there is no established method for prevention. A prospective, randomized, single-blind study was performed to evaluate the efficacy of regular application of povidone-iodine ointment at the catheter site (during the entire time on the study) in peritoneal dialysis. One hundred twenty patients were randomized; three were excluded for not completing the study. Sixty-one patients received application of povidone-iodine and 56 patients received standard care. Povidone-iodine ointment was effective in delaying infectious complications, with a lower proportion of treated patients having infections (exit site and peritonitis) within 140 days of starting dialysis compared with the controls (P = 0.04, Wilcoxon test). This protective benefit was lost after 140 days on dialysis. Staphylococcus aureus infections developed in only two (3.3%) of the treated patients compared with 10 (21.4%) of the controls (P = 0.009), despite the higher rate of S aureus nasal carriage in the treated group (22 of 61 patients [36%] v 14 of 56 patients [25%]).

Citations

Jan 1, 2003·JBI Library of Systematic Reviews·Craig LockwoodTamara Page
Apr 1, 2017·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Cheuk-Chun SzetoEdwina A Brown
Jul 11, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Tayler F L WishartKamal Sud
Oct 3, 2003·The International Journal of Artificial Organs·E ThodisD G Oreopoulos
Apr 9, 2017·The Cochrane Database of Systematic Reviews·Denise CampbellGiovanni Fm Strippoli
Jan 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D AmatoR Paniagua

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